随着组织和循环中 microRNA (miRNA) 表达的数据不断增加，越来越多的证据表明 microRNA 有可能作为癌症诊断和预后的生物标志物以及新的治疗靶点。 miRNA-301a (miR-301a) 的表达水平在多种人类肿瘤类型中发生改变，大量研究揭示了 miR-301a 在肿瘤发生和肿瘤进展中的作用。在此，我们全面总结、比较和对比miR-301a在不同癌症中作用的研究进展。组织和生物体液中 miR-301a 的差异表达模式与癌症诊断、治疗反应和预后有关。 MiR-301a 通过直接或间接调节人类癌症增殖、迁移、侵袭、血管生成以及放射或化疗耐药性来调节多个基因、其他非编码 RNA 和信号级联的表达。癌细胞相关的 miR-301a 通过改变免疫功能和癌症代谢来影响肿瘤微环境。这些发现强调了 miR-301a 在各种人类癌症中的功能作用、临床意义和治疗相关性。© 2024。作者获得 Springer Nature America, Inc. 的独家许可。

With the growing data on microRNA (miRNA) expression in tissues and circulation, there is increasing evidence for the potential of microRNAs to serve as biomarkers in cancer diagnosis and prognosis, as well as novel therapeutic targets. The expression level of miRNA-301a (miR-301a) is altered in a wide range of human tumor types, and numerous studies have revealed the roles of miR-301a in tumorigenesis and tumor progression. Herein, we comprehensively summarize, compare, and contrast the research advancements on the role of miR-301a in different cancers. Differential expression patterns of miR-301a in tissues and biofluids are implicated in cancer diagnosis, treatment response, and prognosis. MiR-301a modulates the expression of multiple genes, other noncoding RNAs, and signaling cascade via direct or indirect regulation in human cancer proliferation, migration, invasion, angiogenesis, and radio- or chemotherapy resistance. Cancer cell-associated miR-301a affects the tumor microenvironment through the alteration of immune function and cancer metabolism. These findings highlight the functional roles, clinical implications, and therapeutic relevance of miR-301a in various human cancers.© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.