与 T-/自然杀伤细胞淋巴瘤相关的猫嗜酸性硬化性纤维增生。
Feline eosinophilic sclerosing fibroplasia associated with T-/natural killer-cell lymphoma.
发表日期:2024 Sep 25
作者:
Andrea Klang, Christof A Bertram, Taryn A Donovan, Linden E Craig, Ingrid Walter, Birgitt Wolfesberger, Brigitte Degasperi, Elisabeth Baszler, Barbara C Rütgen, Sabine E Hammer, Andrea Fuchs-Baumgartinger
来源:
VETERINARY PATHOLOGY
摘要:
猫嗜酸性硬化性纤维增生症 (FESF) 是一种胃肠道和其他部位的增殖性炎症性疾病,在猫中诊断的情况很少见。这种病因不明的实体通常表现为进行性肿块病变,类似于肿瘤过程。在本病例系列中,我们介绍了 17 例与病灶内淋巴瘤相关的 FESF 病例。这种独特淋巴瘤的组织学和免疫组织化学特征表明,肿瘤性淋巴细胞对 CD56 和/或 CD3 呈免疫阳性,表明自然杀伤细胞、自然杀伤 T 细胞或 T 细胞起源。该病例系列首次描述了这种淋巴瘤亚型,并提出了术语“嗜酸性硬化性淋巴瘤”。
Feline eosinophilic sclerosing fibroplasia (FESF) is a proliferative, inflammatory disease of the gastrointestinal tract and other sites, uncommonly diagnosed in the cat. This entity of uncertain etiology typically presents as a progressive mass lesion, mimicking a neoplastic process. In this case series, we present 17 cases of FESF associated with intralesional lymphoma. Histologic and immunohistochemical characterization of this unique lymphoma revealed that the neoplastic lymphocytes were immunopositive for CD56 and/ or CD3, suggesting a natural killer cell, natural killer T-cell, or T-cell origin. This case series represents the first description of this lymphoma subtype, for which the term eosinophilic sclerosing lymphoma is proposed.