癌症免疫疗法的最新进展已被证明比大多数其他疗法更有效。免疫力是身体的第一道防线；然而，癌细胞可以操纵免疫区室在肿瘤进展中发挥多种作用。肿瘤相关巨噬细胞（TAM）是肿瘤微环境中最主要的成分之一，被认为是抗肿瘤抑制因子。不幸的是，TAM 的完整行为仍不清楚且研究不足。 TAM密度与肝细胞癌（HCC）的进展和不良预后直接相关，因此从不同角度研究TAM，绕过所有可能影响其存在、极化、功能和复极化的因素具有重要意义。据报道，不同的表观遗传调控与 HCC 和 TAM 都有直接关系。在此，本综述讨论了对 HCC 中的 TAM 产生积极或消极影响的不同表观遗传调控。

Recent development in immunotherapy for cancer treatment has substantiated to be more effective than most of the other treatments. Immunity is the first line of defence of the body; nevertheless, cancerous cells can manipulate immunity compartments to play several roles in tumour progression. Tumour-associated macrophages (TAMs), one of the most dominant components in the tumour microenvironment, are recognized as anti-tumour suppressors. Unfortunately, the complete behaviour of TAMs is still unclear and understudied. TAM density is directly correlated with the progression and poor prognosis of hepatocellular carcinoma (HCC), therefore studying TAMs from different points of view passing by all the factors that may affect its existence, polarization, functions and repolarization are of great importance. Different epigenetic regulations were reported to have a direct relation with both HCC and TAMs. Here, this review discusses different epigenetic regulations that can affect TAMs in HCC whether positively or negatively.