研究动态
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儿科躯体后颅窝症状量表 (3PFS):后颅窝脑肿瘤儿科住院康复的损伤和结果。

The Pediatric Physiatric Posterior Fossa Symptoms scale (3PFSs): Impairments and outcome in pediatric inpatient rehabilitation for posterior fossa brain tumors.

发表日期:2024 Sep 25
作者: Jennifer Wu, Brian D Wishart, Stephanie E Cohen, Patricia Orme, Susan S Quinn, Donna Nimec
来源: NEURO-ONCOLOGY

摘要:

对后颅窝肿瘤术后神经系统后遗症的临床认识并不一致。本研究旨在描述后颅窝脑肿瘤手术切除后住院康复的儿科患者的功能障碍和康复轨迹。这项研究还介绍了小儿后颅窝症状量表 (3PFS),用于对小儿后颅窝脑肿瘤术后症状进行系列评估。 这项回顾性队列研究包括 49 名年龄在 1.1 至 19.9 岁之间的患者,他们入住于免费的儿科病房。切除后颅窝脑肿瘤后常驻康复医院。儿童功能独立测量 (WeeFIM) 以及入院和出院时的 3PFS 评分是主要结局指标。在整个组中,WeeFIM 评分从入院时的 51.5±23.5 分提高到出院时的 74.2±28.2 分(t=4.34,p<0.001) )。 3PFS 评分也从入院时的 10[IQR=9-12] 分提高到出院时的 8[7-10] 分(t=9.3,p<0.0001)。虽然 WeeFIM 和 3PFS 的变化在功能上实现了统计学上的显着改善,但评分间相关性较低 (p>0.7)。此外,死亡率与较高的出院 3PFSs 评分相关 (p=0.007),但与出院 WeeFIM 评分无关。 对于因后颅窝脑肿瘤导致术后神经系统后遗症的儿科患者,住院康复导致整体和特定领域的功能改善。 3PFS 的初步应用表明了将患者分层到适当康复水平、捕获对康复治疗的功能相关反应以及预测长期结果的潜在适用性。这些初步结果很有希望,但需要在更大的队列中进行额外验证。© 作者 2024。由牛津大学出版社代表神经肿瘤学会出版。版权所有。如需商业重复使用,请联系 reprints@oup.com 获取转载和转载的翻译权。所有其他权限都可以通过我们网站文章页面上的权限链接通过我们的 RightsLink 服务获得 - 如需了解更多信息,请联系journals.permissions@oup.com。
Clinical recognition of the post-operative neurologic sequelae of posterior fossa tumors is inconsistent. This study aimed to characterize functional impairments and recovery trajectories in pediatric patients admitted to inpatient rehabilitation following surgical resection of posterior fossa brain tumors. This study also introduces the Pediatric Physiatric Posterior Fossa Symptom scale (3PFSs) for serial assessment of post-operative symptoms in pediatric posterior fossa brain tumors.This retrospective cohort study included 49 patients aged 1.1 to 19.9 years admitted to a pediatric unit of a free-standing rehabilitation hospital following resection of a posterior fossa brain tumor. Functional Independence Measure for Children (WeeFIM) and 3PFSs scores at admission and discharge were the primary outcome measures.Across the group, WeeFIM score improved from 51.5±23.5 points at admission to 74.2±28.2 points at discharge (t=4.34, p<0.001). The 3PFSs score also showed improvement from 10[IQR=9-12] points at admission to 8[7-10] points at discharge (t=9.3, p<0.0001). While change in both the WeeFIM and 3PFSs captured statistically significant improvement in function, there was low inter-rating correlation (p>0.7). In addition, mortality was correlated with higher discharge 3PFSs score (p=0.007) but not discharge WeeFIM score.In pediatric patients with post-operative neurologic sequelae due to posterior fossa brain tumors, inpatient rehabilitation resulted in global and domain specific functional improvements. This initial application of the 3PFSs demonstrates potential applicability for stratifying patients to appropriate levels of rehabilitation, capturing functionally relevant response to rehabilitation treatment, and prognosticating long-term outcomes. These initial results are promising but require additional validation in a larger cohort.© The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.