研究发现，生命必需 8 (LE8) 分数高与癌症人群和年轻人患心血管疾病 (CVD) 的风险降低相关。然而，LE8 与高尿酸血症 (HUA) CVD 风险之间的关联尚不完全清楚。主要分析包括 6814 名 HUA 参与者。在二次分析中，从主要分析中选择了5,418名参与者来模拟2006年至2010年尿酸（UA）水平的轨迹。使用Cox回归模型研究不同人群中LE8总分与心血管疾病风险之间的关系。在主要分析的随访15.79年中，发生了986起CVD事件。以三分位数1为对照组，三分位数2和三分位数CVD的HR和95％CI分别为0.75（0.65，0.87）和0.56（0.47，0.66）。在二次分析中，低水平和中水平UA减少CVD的个体的HR和95％CI分别为0.49（0.26，0.89）和0.56（0.41，0.76），但在持续高水平的个体中没有发现这种关联。 UA 水平。不同性别的CVD风险不同。不同年龄组心血管疾病风险存在差异，HUA人群心血管疾病风险随着LE8评分的升高而降低，尤其是中青年和女性。然而，值得注意的是，LE8 可能无法降低 UA 水平持续较高的个体患 CVD 的风险。版权所有 © 2024。由 Elsevier Inc. 出版。

Studies have found that a high Life's Essential 8 (LE8) score is associated with a reduced risk of cardiovascular disease(CVD) in cancer populations and young adults. However, the association between LE8 and the risk of CVD in hyperuricemia (HUA) is not fully understood.The main analysis included 6814 HUA participants. In a secondary analysis, 5,418 participants were selected from the main analysis to model the trajectory of uric acid (UA) levels from 2006 to 2010. Cox regression model was used to investigate the relationship between LE8 total score and cardiovascular disease risk in different populations.Follow-up of 15.79 years in the main analysis, 986 CVD events occurred. With tertile 1 as the control group, the HR and 95 % CI of CVD in tertile 2 and tertile 3 were 0.75(0.65,0.87) and 0.56(0.47,0.66). In the secondary analysis, the HR and 95 %CI of individuals with low and medium levels of UA reduced CVD were 0.49(0.26,0.89) and 0.56(0.41,0.76), respectively, but this association was not found in individuals with sustained high UA levels. The risk of CVD was different between the sexes. There are differences in cardiovascular disease risk among different age groups.The risk of CVD in HUA population decreased with the increase of LE8 score, especially in young and middle-aged people and women. However, it is important to note that LE8 may not reduce the risk of CVD in individuals with sustained high UA levels.Copyright © 2024. Published by Elsevier Inc.