甲胎蛋白（AFP）被广泛认为是监测肝细胞癌（HCC）的重要标志物，利用两种不同转导机制对其进行监测是避免假阳性或假阴性风险的有效方法。在本文中，Au@Cu/Cu2O-rGO被用作光热转换器和促动器来促进过氧化氢（H2O2）的分解，并进一步设计为双模式检测的探针以定量评估AFP。相对于单一材料，复合纳米材料的光热转换效率 (η) 高达 54.9%，催化产生的信号高达 1.6 倍。根据生成的温度和电流信号，AFP 的检测范围为 0.01-100 ng/mL，检测限 (LOD) 分别为 5.62 pg/mL 和 1.23 pg/mL。双模式检测结合了便携性和高精度，可用于人类健康系统的检测。版权所有 © 2024 Elsevier B.V. 保留所有权利。

α-Fetoprotein (AFP) is widely recognized as an important marker for monitoring hepatocellular carcinoma (HCC), and its monitoring using two different transduction mechanisms is an effective way to avoid the risk of false positives or false negatives. In this paper, Au@Cu/Cu2O-rGO was used as a photothermal converter as well as an actuator to promote the decomposition of hydrogen peroxide (H2O2), which was further designed as a probe for dual-mode detection to quantitatively assess AFP. The composite nanomaterials possessed photothermal conversion efficiencies (η) of up to 54.9 % and catalytically generated signals up to 1.6 times greater, relative to a single material. Based on the generated temperature and current signals, AFP has been sensitively detected in the range of 0.01-100 ng/mL, with limits of detection (LOD) of 5.62 pg/mL and 1.23 pg/mL, respectively. The dual-mode assay combines portability with high accuracy for the detection of human health systems.Copyright © 2024 Elsevier B.V. All rights reserved.