感觉神经打开了癌症扩散的 TOLL-7 大门。
Sensory nerves unlock the TOLL-7 gate for cancer spread.
发表日期：2024 Oct
作者：
R K Subbarao Malireddi, Thirumala-Devi Kanneganti
来源：
TRENDS IN IMMUNOLOGY
摘要：
癌症劫持神经系统进行生长和扩散。因此，破坏神经元-癌症串扰有望阻止转移。最近，Padmanaban 等人。报道了新的治疗靶点，并表明乳腺癌细胞激活感觉神经元分泌神经肽物质 P (SP)，导致单链 (ss)RNA 释放和非经典 Toll 样受体 (TLR)7 信号传导驱动转移。版权所有 © 2024 年。由爱思唯尔有限公司出版。
Cancers hijack the nervous system for growth and spread. Thus, disrupting neuron-cancer crosstalk holds promise for blocking metastasis. Recently, Padmanaban et al. reported new therapeutic targets and showed that breast cancer cells activate sensory neurons to secrete the neuropeptide substance P (SP), leading to single-strand (ss)RNA release and noncanonical Toll-like receptor (TLR)7 signaling that drives metastasis.Copyright © 2024. Published by Elsevier Ltd.