这项研究调查了影响日本普通人群慢性肾病死亡率的传统心血管和生活方式风险因素，这是日本普通人群的根本原因。我们对来自日本合作队列的 44,792 名男性和 61,522 名年龄在 40-79 岁之间的女性进行了一项为期 18.8 年的跟踪研究1986 年至 1990 年间癌症风险评估研究。使用 Cox 比例风险模型分析慢性肾病风险因素与死亡率之间的关联。在随访期间，373 名参与者（185 名男性和 188 名女性）死于慢性肾病肾脏疾病。体重指数≥27 kg/m2（男性风险比[95%置信区间] = 2.00 [1.19-3.36]，女性1.91 [1.19-3.07]，而女性风险比为23.0-24.9 kg/m2）高血压病史（男性 2.32 [1.67-3.22]，女性 2.01 [1.44-2.81]）和糖尿病史（男性 5.21 [3.68-7.37]，女性 7.10 [4.93-10.24]）与男女因慢性肾病死亡的风险增加。在男性中，吸烟也与风险增加相关（1.91 [1.25-2.90]），而当前饮酒（<23克/天为0.58 [0.34-0.98]，23-45克/天为0.48 [0.29-0.80]） ≥46 克/天为 0.53 [0.32-0.86]) 和每周锻炼 ≥5 小时 (0.42 [0.18-0.96]) 与较低风险相关。在女性中也观察到与吸烟和饮酒类似但不显着的关联。除了高血压病史和糖尿病病史外，体重指数、吸烟状况、饮酒状况和运动习惯也与死亡风险相关。慢性肾脏疾病。

This study investigated conventional cardiovascular and lifestyle risk factors affecting mortality from chronic kidney disease as the underlying cause in the general Japanese population.We conducted an 18.8-year follow-up study of 44,792 men and 61,522 women aged 40-79 from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk between 1986 and 1990. Cox proportional hazard models were used to analyze the association between risk factors and mortality from chronic kidney disease.During the follow-up period, 373 participants (185 men and 188 women) died from chronic kidney disease. A body mass index of ≥27 kg/m2 (hazard ratio [95% confidence interval] = 2.00 [1.19-3.36] for men and 1.91 [1.19-3.07] for women, compared with 23.0-24.9 kg/m2), a history of hypertension (2.32 [1.67-3.22] for men and 2.01 [1.44-2.81] for women) and a history of diabetes mellitus (5.21 [3.68-7.37] for men and 7.10 [4.93-10.24] for women) were associated with an increased risk of mortality from chronic kidney disease in both sexes. In men, smoking was also associated with an increased risk (1.91 [1.25-2.90]), while current drinking (0.58 [0.34-0.98] for <23 g/day, 0.48 [0.29-0.80] for 23-45 g/day and 0.53 [0.32-0.86] for ≥46 g/day) and exercising ≥5 hours/week (0.42 [0.18-0.96]) were associated with a lower risk. Similar but non-significant associations for smoking and drinking were observed in women.In addition to a history of hypertension and a history of diabetes mellitus, body mass index, smoking status, drinking status, and exercise habits were associated with the risk of mortality from chronic kidney disease.