卵巢癌幸存者中巨细胞病毒感染与癌症相关的认知障碍和周围神经病的关联
Associations of cytomegalovirus infection with cancer-related cognitive impairment and peripheral neuropathy in ovarian cancer survivors
影响因子:4.10000
分区:医学2区 Top / 妇产科学1区 肿瘤学2区
发表日期:2024 Dec
作者:
Xuan Li, Peter A Argenta, Katherine Brown, Kate Honeyfield, Devon Hunter-Schlichting, Morgan Gruner, Deanna Teoh, Lauren C Peres, Melissa Geller, Heather H Nelson, Rachel I Vogel
摘要
评估卵巢癌幸存者中与癌症相关认知障碍（CRCI）（CRCI）（CRCI）（CRCI）（CRCI）的症状之间的关联。我们在卵巢癌的诊断中进行了一项诊断为卵巢癌，主要腹膜癌，或在任何学术癌症临床上的诊断型卵巢癌的诊断中进行诊断。参与者完成了一次性调查并提供了血液样本。使用数字PCR测量等离子体病毒DNA水平，≥100份/ml血浆被认为是活性感染（CMV+，EBV+作为对照）。我们使用患者报告的结果测量信息系统（Promis）认知功能短表8A和癌症治疗/妇科肿瘤学组 - 神经毒性组（FACT/GOG-NTX）的症状评估，分别使用患者报告的结果测量信息系统（PROMIS）认知函数来测量CRCI和周围神经病的症状。比较了整个组中的主动CMV感染状态以及使用t检验和线性回归模型接受主动治疗的亚组中的症状。152参与者。共有59名（38.8％）的参与者为CMV+。调整了潜在的混杂变量后，CMV+自我报告的个体的周围神经病症状明显比CMV-的人（P = 0.04）。在目前接受化疗的参与者的亚组中，与CMV的个体相比，CMV+的个体的认知功能明显降低（p = 0.03）；在完整的队列中未观察到这一点。在结局和EBV感染之间未观察到任何关联。活性CMV感染在该幸存者人群中很常见，可能与CRCI和神经病的更多症状有关。
Abstract
To assess the associations between active CMV infection and patient-reported symptoms of cancer-related cognitive impairment (CRCI) and peripheral neuropathy in ovarian cancer survivors.We conducted a cross-sectional study among individuals with a diagnosis of ovarian cancer, primary peritoneal cancer, or fallopian tube cancer from academic and community cancer clinics at any time point after completion of front-line chemotherapy. Participants completed a one-time survey and provided a blood sample. Plasma virus DNA levels were measured using digital PCR, with ≥100 copies/mL of plasma considered active infection (CMV+, EBV+ as a control). We measured symptoms of CRCI and peripheral neuropathy using the Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive Function short form 8a and Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - Neurotoxicity (FACT/GOG-NTX) subscale measurements, respectively. Symptoms were compared by active CMV infection status in the full group and among the subgroup receiving active treatment using t-tests and linear regression models.152 participants were included. A total of 59 (38.8 %) participants were CMV+. After adjustment for potential confounding variables, individuals who were CMV+ self-reported significantly more symptoms of peripheral neuropathy that those who were CMV- (p = 0.04). In the subgroup of participants currently receiving chemotherapy, individuals who were CMV+ had significantly lower perceived cognitive functioning compared to individuals who were CMV- (p = 0.03); this was not observed in the full cohort. No associations were observed between outcomes and EBV infection.Active CMV infection is common in this survivor population and may be associated with more symptoms of CRCI and neuropathy.