为了评估卵巢癌幸存者中活动性 CMV 感染与患者报告的癌症相关认知障碍 (CRCI) 和周围神经病变症状之间的关联。我们在诊断为卵巢癌、原发性腹膜癌、或在完成一线化疗后的任何时间点从学术和社区癌症诊所获得的输卵管癌。参与者完成了一次性调查并提供了血液样本。使用数字 PCR 测量血浆病毒 DNA 水平，血浆≥100 拷贝/mL 视为活动性感染（CMV、EBV 作为对照）。我们分别使用患者报告结果测量信息系统 (PROMIS) 认知功能简表 8a 和癌症治疗/妇科肿瘤组功能评估 - 神经毒性 (FACT/GOG-NTX) 子量表测量来测量 CRCI 和周围神经病变的症状。使用 t 检验和线性回归模型，通过全组和接受积极治疗的亚组中的主动 CMV 感染状态来比较症状。纳入了 152 名参与者。共有 59 名 (38.8%) 参与者患有 CMV。在调整潜在的混杂变量后，CMV 患者自我报告的周围神经病变症状明显多于 CMV 阴性患者 (p = 0.04)。在目前接受化疗的参与者亚组中，与 CMV- 个体相比，CMV 个体的感知认知功能显着较低 (p = 0.03)；在整个队列中没有观察到这一点。没有观察到结果与 EBV 感染之间存在关联。活动性 CMV 感染在幸存者群体中很常见，并且可能与更多 CRCI 和神经病变症状相关。版权所有 © 2024 Elsevier Inc. 保留所有权利。

To assess the associations between active CMV infection and patient-reported symptoms of cancer-related cognitive impairment (CRCI) and peripheral neuropathy in ovarian cancer survivors.We conducted a cross-sectional study among individuals with a diagnosis of ovarian cancer, primary peritoneal cancer, or fallopian tube cancer from academic and community cancer clinics at any time point after completion of front-line chemotherapy. Participants completed a one-time survey and provided a blood sample. Plasma virus DNA levels were measured using digital PCR, with ≥100 copies/mL of plasma considered active infection (CMV+, EBV+ as a control). We measured symptoms of CRCI and peripheral neuropathy using the Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive Function short form 8a and Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - Neurotoxicity (FACT/GOG-NTX) subscale measurements, respectively. Symptoms were compared by active CMV infection status in the full group and among the subgroup receiving active treatment using t-tests and linear regression models.152 participants were included. A total of 59 (38.8 %) participants were CMV+. After adjustment for potential confounding variables, individuals who were CMV+ self-reported significantly more symptoms of peripheral neuropathy that those who were CMV- (p = 0.04). In the subgroup of participants currently receiving chemotherapy, individuals who were CMV+ had significantly lower perceived cognitive functioning compared to individuals who were CMV- (p = 0.03); this was not observed in the full cohort. No associations were observed between outcomes and EBV infection.Active CMV infection is common in this survivor population and may be associated with more symptoms of CRCI and neuropathy.Copyright © 2024 Elsevier Inc. All rights reserved.