结构决定了道路：乳腺癌亚型以不同的方式塑造了早期脑转移生态位。
Architecture sets the path: Breast cancer subtypes differently shape the early brain metastatic niche.
发表日期：2024 Oct 14
作者：
Menno Boon, Leila Akkari
来源：
CANCER CELL
摘要：
播散性癌细胞在大脑中定植的能力高度依赖于最初的生存线索，通常会引起早期的微环境适应。在本期《癌细胞》中，Gan 等人。揭示了早期 HER2 乳腺癌和三阴性乳腺癌脑转移中形成基质相互作用的不同肿瘤结构，为亚型依赖性患者分层提供了基本原理。版权所有 © 2024 Elsevier Inc. 保留所有权利。
The ability of disseminated cancer cells to colonize the brain is highly dependent on initial survival cues, often evoking early microenvironmental adaptations. In this issue of Cancer Cell, Gan et al. unveil disparate tumor architectures in early stage HER2+ breast cancer and triple-negative breast cancer brain metastases that shape stromal interactions, providing a rationale for subtype-dependent patient stratification.Copyright © 2024 Elsevier Inc. All rights reserved.