胰岛素样生长因子 2 mRNA 结合蛋白 1 (IGF2BP1) 是单链 RNA 结合蛋白保守家族 (IGF2BP1-3) 的成员，在多种胎儿组织、胎盘等中表达超过十六种癌症类型，但仅存在于有限数量的正常成人组织中。 IGF2BP1 是某些 mRNA 从细胞核转运到细胞质所必需的，这些 mRNA 通过影响其稳定性、翻译或定位，在胚胎发生、癌变和多药耐药性 (MDR) 中发挥重要作用。本综述的目的是收集并提供有关癌症 MDR 机制的信息以及 IGF2BP1 在此背景下的重要性。在这篇综述中，我们将概述 IGF2BP1，包括其组织分布、表达、肿瘤发生背景下的分子靶点及其抑制剂。我们的主要重点是阐明 IGF2BP1 和 MDR 之间的相互作用，特别是 ABC 转运蛋白介导的化疗耐药性。版权所有 © 2024。由 Elsevier Inc. 出版。

The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1), a member of a conserved family of single-stranded RNA-binding proteins (IGF2BP1-3), is expressed in a broad range of fetal tissues, placenta and more than sixteen cancer types but only in a limited number of normal adult tissues. IGF2BP1is required for the transport from nucleus to cytoplasm of certain mRNAs that play essential roles in embryogenesis, carcinogenesis, and multidrug resistance (MDR), by affecting their stability, translation, or localization. The purpose of this review is to gather and present information on MDR mechanisms in cancer and the significance of IGF2BP1 in this context. Within this review, we will provide an overview of IGF2BP1, including its tissue distribution, expression, molecular targets in the context of tumorigenesis and its inhibitors. Our main focus will be on elucidating the interplay between IGF2BP1 and MDR, particularly with regard to chemoresistance mediated by ABC transporters.Copyright © 2024. Published by Elsevier Inc.