新出现的担忧将牙周炎与一系列癌症（尤其是甲状腺癌）联系起来，尽管对这些关联的研究仍处于初期阶段。这项基于人群的研究旨在利用台湾纵向健康保险数据库 2010 (LHID2010) 调查甲状腺癌与慢性牙周炎的关联。这项病例对照研究利用 LHID2010，选择了 2,775 名诊断患有甲状腺癌的患者，并根据年龄与 8,325 名对照者进行匹配使用倾向得分匹配来确定性别、收入以及是否存在糖尿病、高血压、高脂血症、人乳头瘤病毒感染和烟草使用障碍。采用多因素Logistic回归模型评估甲状腺癌与慢性牙周炎的关系。卡方分析显示，甲状腺癌诊断者与对照组之间慢性牙周炎的患病率存在​​显着差异，患病率分别为38.5%和24.1%。 %，p 值小于 0.001。与对照组相比，甲状腺癌患者既往患有慢性牙周炎的比值比 (OR) 为 1.991，95% 置信区间 (CI) 为 1.816-2.184，p 值小于 0.001。性别之间的相关性相似，男性和女性的调整后 OR 分别为 1.991 (95% CI = 1.816∼2.184) 和 1.962 (95% CI = 1.765-2.182)，表明男性和女性慢性牙周炎患病率具有统计学意义。与对照组相比，诊断出患有甲状腺癌的女性患者。研究结果强调慢性牙周炎是甲状腺癌的潜在危险因素，强调了综合健康监测和包括口腔健康在内的预防策略的重要性。本研究旨在探讨甲状腺与甲状腺癌之间的联系癌症和慢性牙周炎。利用台湾2010年纵向健康保险数据库（LHID2010），我们选择了2,775名甲状腺癌患者，并根据年龄、性别、收入和其他健康状况（如糖尿病、高血压、高胆固醇、HPV感染）将他们与8,325名未患甲状腺癌的人进行匹配。和吸烟习惯。该研究使用统计模型来检查甲状腺癌和慢性牙周炎之间的关系。研究结果显示，38.5%的甲状腺癌患者患有慢性牙周炎，而对照组的这一比例为24.1%。甲状腺癌患者患慢性牙周炎的几率几乎是其两倍。这种模式对于男性和女性来说都是一致的。该研究强调了慢性牙周炎与甲状腺癌之间的密切联系，并强调了提高公众对牙周炎潜在风险认识的重要性。© 2024 美国牙周病学会。

Emerging concerns link periodontitis to an array of cancers, notably thyroid cancer, though investigations into these associations are still in the nascent stages. This population-based study aimed to investigate the association of thyroid cancer with chronic periodontitis using Taiwan's Longitudinal Health Insurance Database 2010 (LHID2010).This case-control study utilized LHID2010, selecting 2,775 patients diagnosed with thyroid cancer, matched with 8,325 controls based on age, sex, income, and the presence of diabetes, hypertension, hyperlipidemia, human papillomavirus infection, and tobacco use disorder using propensity-score matching. Multivariate logistic regression models were used to evaluate the association of thyroid cancer with chronic periodontitis.A chi-squared analysis demonstrated a significant disparity in the prevalence of chronic periodontitis between those diagnosed with thyroid cancer and the controls, with prevalence rates of 38.5% and 24.1% respectively, and a p-value less than 0.001. The odds ratio (OR) for having prior chronic periodontitis among patients with thyroid cancer compared to controls was 1.991, with a 95% confidence interval (CI) of 1.816-2.184 and a p-value less than 0.001. The association was similar between sexes, yielding adjusted ORs of 1.991 (95% CI = 1.816∼2.184) for men and 1.962 (95% CI = 1.765-2.182) for women, indicating a statistically significant higher prevalence of chronic periodontitis in both male and female patients diagnosed with thyroid cancer compared to their control counterparts.The findings highlight chronic periodontitis as a potential risk factor for thyroid cancer, underscoring the importance of integrated health surveillance and preventive strategies that encompass oral health.This study aimed to explore the link between thyroid cancer and chronic periodontitis. Using Taiwan's Longitudinal Health Insurance Database 2010 (LHID2010), we selected 2,775 patients with thyroid cancer and matched them with 8,325 individuals without the disease based on age, sex, income, and other health conditions such as diabetes, hypertension, high cholesterol, HPV infection, and smoking habits. The study used statistical models to examine the relationship between thyroid cancer and chronic periodontitis. The findings showed that 38.5% of thyroid cancer patients had chronic periodontitis, compared to 24.1% of the control group. The odds of having chronic periodontitis were nearly twice as high in thyroid cancer patients. This pattern was consistent for both men and women. The study underscores the strong connection between chronic periodontitis and thyroid cancer, emphasizing the importance of raising public awareness about the potential risks of periodontitis.© 2024 American Academy of Periodontology.