一项关于甲状腺癌与慢性牙周炎关系的基于人群的研究

新兴关注点将牙周炎与多种癌症相关联，尤其是甲状腺癌，但相关研究仍处于初步阶段。本人群基础研究旨在利用台湾的《纵向健康保险数据库2010》（LHID2010）调查甲状腺癌与慢性牙周炎的关系。采用病例对照设计，从LHID2010中筛选出2775名甲状腺癌患者，并根据年龄、性别、收入以及糖尿病、高血压、高脂血症、人乳头瘤病毒感染和吸烟障碍等健康状况进行倾向性匹配，共匹配出8325名对照组。采用多变量逻辑回归模型评估甲状腺癌与慢性牙周炎的关联性。卡方检验显示，甲状腺癌患者与对照组在慢性牙周炎的患病率存在显著差异，患病率分别为38.5%和24.1%，p值<0.001。甲状腺癌患者中有慢性牙周炎的优势比（OR）为1.991（95% CI：1.816-2.184），p值<0.001。男性和女性中的关联性类似，调整后OR分别为1.991（95% CI：1.816∼2.184）和1.962（95% CI：1.765-2.182），均显示甲状腺癌患者中慢性牙周炎的患病率显著高于对照组。研究强调慢性牙周炎可能是甲状腺癌的风险因素，提示应加强口腔健康的整体监测与预防策略。该研究旨在探讨甲状腺癌与慢性牙周炎的关系，利用台湾的LHID2010数据库，筛选出2775名甲状腺癌患者并匹配8,325名无此病的个体，依据年龄、性别及其他健康条件进行匹配。采用统计模型分析两者关系。结果显示，甲状腺癌患者中38.5%同时患有慢性牙周炎，而对照组为24.1%，前者患有牙周炎的可能性几乎是后者的两倍。此规律在男女中都成立。研究强调慢性牙周炎与甲状腺癌之间的密切联系，呼吁公众关注牙周炎的潜在风险。

Emerging concerns link periodontitis to an array of cancers, notably thyroid cancer, though investigations into these associations are still in the nascent stages. This population-based study aimed to investigate the association of thyroid cancer with chronic periodontitis using Taiwan's Longitudinal Health Insurance Database 2010 (LHID2010).This case-control study utilized LHID2010, selecting 2,775 patients diagnosed with thyroid cancer, matched with 8,325 controls based on age, sex, income, and the presence of diabetes, hypertension, hyperlipidemia, human papillomavirus infection, and tobacco use disorder using propensity-score matching. Multivariate logistic regression models were used to evaluate the association of thyroid cancer with chronic periodontitis.A chi-squared analysis demonstrated a significant disparity in the prevalence of chronic periodontitis between those diagnosed with thyroid cancer and the controls, with prevalence rates of 38.5% and 24.1% respectively, and a p-value less than 0.001. The odds ratio (OR) for having prior chronic periodontitis among patients with thyroid cancer compared to controls was 1.991, with a 95% confidence interval (CI) of 1.816-2.184 and a p-value less than 0.001. The association was similar between sexes, yielding adjusted ORs of 1.991 (95% CI = 1.816∼2.184) for men and 1.962 (95% CI = 1.765-2.182) for women, indicating a statistically significant higher prevalence of chronic periodontitis in both male and female patients diagnosed with thyroid cancer compared to their control counterparts.The findings highlight chronic periodontitis as a potential risk factor for thyroid cancer, underscoring the importance of integrated health surveillance and preventive strategies that encompass oral health.This study aimed to explore the link between thyroid cancer and chronic periodontitis. Using Taiwan's Longitudinal Health Insurance Database 2010 (LHID2010), we selected 2,775 patients with thyroid cancer and matched them with 8,325 individuals without the disease based on age, sex, income, and other health conditions such as diabetes, hypertension, high cholesterol, HPV infection, and smoking habits. The study used statistical models to examine the relationship between thyroid cancer and chronic periodontitis. The findings showed that 38.5% of thyroid cancer patients had chronic periodontitis, compared to 24.1% of the control group. The odds of having chronic periodontitis were nearly twice as high in thyroid cancer patients. This pattern was consistent for both men and women. The study underscores the strong connection between chronic periodontitis and thyroid cancer, emphasizing the importance of raising public awareness about the potential risks of periodontitis.