肿瘤细胞在缺乏营养和氧气的微环境中生长。癌症相关成纤维细胞（CAF）作为肿瘤微环境的主要组成部分，通过代谢重塑在应激条件下具有很强的生存能力。此外，CAF 受到肿瘤细胞的教育，并通过代谢通讯帮助它们适应恶劣的微环境。通过诱导分解代谢，CAF 将营养物质释放到微环境中，这些营养物质被肿瘤细胞吸收以满足其代谢需求。此外，CAF可以将癌细胞产生的有毒代谢废物回收成高能物质，使癌细胞能够进行生物合成。它们的代谢串扰还增强了 CAF 的促肿瘤表型，并重塑了促进肿瘤细胞转移和免疫逃逸的微环境。在这篇综述中，我们分析了肿瘤细胞和 CAF 之间代谢串扰的影响和机制。我们还从 CAF 异质性、空间代谢组学和患者来源的肿瘤类器官（PDO）等角度分析了该领域的未来前景。这些信息可能会加深对 CAF 调节的肿瘤代谢的了解，并为基于代谢的抗癌策略的开发提供新的见解。版权所有 © 2024。由 Elsevier B.V. 出版。

Tumor cells grow in a microenvironment with a lack of nutrients and oxygen. Cancer-associated fibroblasts (CAFs) as one major component of tumor microenvironment have strong ability to survive under stressful conditions through metabolic remodelling. Furthermore, CAFs are educated by tumor cells and help them adapt to the hostile microenvironment through their metabolic communication. By inducing catabolism, CAFs release nutrients into the microenvironment which are taken up by tumor cells to satisfy their metabolic requirements. Furthermore, CAFs can recycle toxic metabolic wastes produced by cancer cells into energetic substances, allowing cancer cells to undergo biosynthesis. Their metabolic crosstalk also enhances CAFs' pro-tumor phenotype and reshape the microenvironment facilitating tumor cells' metastasis and immune escape. In this review, we have analyzed the effect and mechanisms of metabolic crosstalk between tumor cells and CAFs. We also analyzed the future perspectives in this area from the points of CAFs heterogeneity, spatial metabonomics and patient-derived tumor organoids (PDOs). These information may deepen the knowledge of tumor metabolism regulated by CAFs and provide novel insights into the development of metabolism-based anti-cancer strategies.Copyright © 2024. Published by Elsevier B.V.