长期非编码RNA在泛素化，蛋白质降解和人类疾病中
Long noncoding RNAs in ubiquitination, protein degradation, and human diseases
影响因子:3.10000
分区:生物学3区 / 生物物理3区 生化与分子生物学4区
发表日期:2024 Dec
作者:
Prarthana Guha, Avisankar Chini, Ashcharya Rishi, Subhrangsu S Mandal
摘要
蛋白质的稳定性和周转在正常的细胞和生理过程中至关重要，它们的正直可能导致不良蛋白的积累，导致细胞功能不全，神经变性，线粒体故障和代谢破坏。与蛋白质降解相关的信号传导机制是复杂的，并且经过广泛的研究。许多蛋白质和酶机已经与蛋白质降解的调节有关。尽管有这些见解，但我们对蛋白质降解机制的理解仍然有限。新兴研究表明，长期非编码RNA（LNCRNA）在各种细胞和生理过程中起关键作用，包括代谢，细胞稳态和蛋白质更新。 LNCRNA是大核酸（> 200 nt）可以与各种蛋白质和其他核酸相互作用，并调节蛋白质结构和功能，从而导致细胞信号传导过程的调节。 LNCRNA广泛分布在细胞类型中，可能表现出组织特异性表达。它们在包括血液和尿液在内的体液中检测到。在包括癌症，神经系统疾病，免疫疾病等的各种人类疾病中，它们的表情也会改变。 LNCRNA被认为是新型的生物标志物和治疗靶标。这篇评论文章的重点是非编码RNA（NCRNA）的新兴作用，尤其是长期非编码RNA（LNCRNA），在蛋白质多泛素化和蛋白酶体降解的调节中。
Abstract
Protein stability and turnover is critical in normal cellular and physiological process and their misregulation may contribute to accumulation of unwanted proteins causing cellular malfunction, neurodegeneration, mitochondrial malfunction, and disrupted metabolism. Signaling mechanism associated with protein degradation is complex and is extensively studied. Many protein and enzyme machineries have been implicated in regulation of protein degradation. Despite these insights, our understanding of protein degradation mechanisms remains limited. Emerging studies suggest that long non-coding RNAs (lncRNAs) play critical roles in various cellular and physiological processes including metabolism, cellular homeostasis, and protein turnover. LncRNAs, being large nucleic acids (>200 nt long) can interact with various proteins and other nucleic acids and modulate protein structure and function leading to regulation of cell signaling processes. LncRNAs are widely distributed across cell types and may exhibit tissue specific expression. They are detected in body fluids including blood and urine. Their expressions are also altered in various human diseases including cancer, neurological disorders, immune disorder, and others. LncRNAs are being recognized as novel biomarkers and therapeutic targets. This review article focuses on the emerging role of noncoding RNAs (ncRNAs), particularly long noncoding RNAs (lncRNAs), in the regulation of protein polyubiquitination and proteasomal degradation.Published by Elsevier B.V.