蛋白质稳定性和周转在正常细胞和生理过程中至关重要，它们的失调可能会导致不需要的蛋白质积累，从而导致细胞功能障碍、神经变性、线粒体功能障碍和新陈代谢紊乱。与蛋白质降解相关的信号机制很复杂，并且得到了广泛的研究。许多蛋白质和酶机器与蛋白质降解的调节有关。尽管有这些见解，我们对蛋白质降解机制的理解仍然有限。新兴研究表明，长链非编码 RNA (lncRNA) 在各种细胞和生理过程中发挥着关键作用，包括新陈代谢、细胞稳态和蛋白质周转。 LncRNA 是大核酸（>200 nt 长），可以与各种蛋白质和其他核酸相互作用，调节蛋白质结构和功能，从而调节细胞信号传导过程。 LncRNA 广泛分布于各种细胞类型，并可能表现出组织特异性表达。它们可以在血液和尿液等体液中检测到。它们的表达也在多种人类疾病中发生改变，包括癌症、神经系统疾病、免疫疾病等。 LncRNA 被认为是新型生物标志物和治疗靶点。这篇综述文章重点关注非编码 RNA (ncRNA)，特别是长非编码 RNA (lncRNA) 在蛋白质多泛素化和蛋白酶体降解调节中的新兴作用。由 Elsevier B.V 出版。

Protein stability and turnover is critical in normal cellular and physiological process and their misregulation may contribute to accumulation of unwanted proteins causing cellular malfunction, neurodegeneration, mitochondrial malfunction, and disrupted metabolism. Signaling mechanism associated with protein degradation is complex and is extensively studied. Many protein and enzyme machineries have been implicated in regulation of protein degradation. Despite these insights, our understanding of protein degradation mechanisms remains limited. Emerging studies suggest that long non-coding RNAs (lncRNAs) play critical roles in various cellular and physiological processes including metabolism, cellular homeostasis, and protein turnover. LncRNAs, being large nucleic acids (>200 nt long) can interact with various proteins and other nucleic acids and modulate protein structure and function leading to regulation of cell signaling processes. LncRNAs are widely distributed across cell types and may exhibit tissue specific expression. They are detected in body fluids including blood and urine. Their expressions are also altered in various human diseases including cancer, neurological disorders, immune disorder, and others. LncRNAs are being recognized as novel biomarkers and therapeutic targets. This review article focuses on the emerging role of noncoding RNAs (ncRNAs), particularly long noncoding RNAs (lncRNAs), in the regulation of protein polyubiquitination and proteasomal degradation.Published by Elsevier B.V.