用髓磷脂喂养愤怒。
Feeding the wrath with myelin.
发表日期：2024 Oct
作者：
Sourav Ghosh, Carla V Rothlin
来源：
TRENDS IN IMMUNOLOGY
摘要：
Kloosterman 及其同事研究了放射治疗期间的分子和细胞变化以及胶质母细胞瘤分子亚型的疾病复发。他们发现了在原神经/少突胶质祖细胞样向间充质样转变过程中存在独特的免疫癌细胞代谢串扰，其中巨噬细胞以富含胆固醇的髓磷脂碎片为食，为间充质肿瘤细胞提供脂质，从而促进胶质母细胞瘤的生长。版权所有 © 2024 Elsevier有限公司保留所有权利。
Kloosterman and colleagues studied molecular and cellular changes during radiation therapy and disease recurrence across molecular subtypes of glioblastoma. They uncovered a distinct immune-cancer cell metabolic crosstalk during proneural/oligodendrocyte progenitor cell-like to mesenchymal-like transition, wherein macrophages feed on cholesterol-rich myelin debris to provide lipids to mesenchymal tumor cells, thereby fueling glioblastoma growth.Copyright © 2024 Elsevier Ltd. All rights reserved.