aristolochic酸与肝癌之间的揭开相关性：时空异质性现象
Unveiling correlations between aristolochic acids and liver cancer: spatiotemporal heterogeneity phenomenon
影响因子:5.70000
分区:医学2区 / 全科医学与补充医学2区 药学2区
发表日期:2024 Sep 28
作者:
Chengxian Li, Xinyu Li, Ming Niu, Dake Xiao, Ye Luo, Yinkang Wang, Zhi-E Fang, Xiaoyan Zhan, Xu Zhao, Mingxia Fang, Jiabo Wang, Xiaohe Xiao, Zhaofang Bai
摘要
阿里斯洛胆酸是具有相似结构骨骼和化学特性的Aristolochiaceae中的一类天然化合物。暴露于阿里斯洛胆道是严重肾脏疾病和尿液系统癌的危险因素。然而，尚不清楚阿里斯洛胆道向肝脏的致癌性（这是阿里斯洛胆道代谢的主要部位）尚不清楚。尽管已经在肝脏中检测到了aristolochicAcid诱导的突变的特征指纹，并且已知aristolochicacs已知是肝毒性的，但是否尚待验证aristolochicain是否可以直接引起肝癌。这篇综述总结了实验动物中阿里斯洛胆道的长期致癌性研究的发现。我们建议，这些植物化学物质的致癌性中时空异质性可以解释为什么在成年个体中从未发现过引起肝癌的阿里斯托胆料酸的直接证据。我们还概述了减轻亚里士醇胆道诱导的肝毒性的方法，以更好地解决相关的全球安全问题，并为将来的研究提供了方向和建议。
Abstract
Aristolochic acids are a class of naturally occurring compounds in Aristolochiaceae that have similar structural skeletons and chemical properties. Exposure to aristolochic acids is a risk factor for severe kidney disease and urinary system cancer. However, the carcinogenicity of aristolochic acids to the liver, which is the main site of aristolochic acid metabolism, is unclear. Although the characteristic fingerprint of aristolochic acid-induced mutations has been detected in the liver and aristolochic acids are known to be hepatotoxic, whether aristolochic acids can directly cause liver cancer is yet to be verified. This review summarizes the findings of long-term carcinogenicity studies of aristolochic acids in experimental animals. We propose that spatiotemporal heterogeneity in the carcinogenicity of these phytochemicals could explain why direct evidence of aristolochic acids causing liver cancer has never been found in adult individuals. We also summarized the reported approaches to mitigate aristolochic acid-induced hepatotoxicity to better address the associated global safety issue and provide directions and recommendations for future investigation.