本研究旨在探讨二维超声（2D-US）联合超声造影（CEUS）在鉴别诊断良性、交界性卵巢肿瘤（BOTs）和恶性卵巢上皮肿瘤中的临床应用价值。回顾性研究2018年12月至2023年11月北京大学人民医院收治的108例经手术病理证实为OETs的患者的临床资料。采用卡方检验、受试者工作特征（ROC）曲线和随机森林模型分析2D-US联合CEUS对OET的诊断价值。108例OET中，良性23例，BOT 34例，BOT 34例。 51例为恶性。卡方检验证实造影剂的灌注模式在 OET 的鉴别诊断中起着重要作用。与良性组相比，BOTs在灌注时相和强化强度方面无显着差异，但BOTs消退时间较早（P < 0.05）。与BOT相比，恶性肿瘤组灌注更早，增强强度更高，消退时间无显着差异。 ROC曲线结果表明，2D-US和CEUS联合诊断OET的效率在敏感性、特异性、准确性和AUC方面均显着高于单一诊断技术。随机森林模型结果显示，在OET鉴别诊断的各种参数中，灌注模式是最重要的因素。2D-US联合CEUS有助于提高良性、BOT和恶性OET的鉴别诊断效率。© 2024。作者。

The aim of this study was to explore the clinical application value of two-dimensional ultrasound (2D-US) combined with contrast-enhanced ultrasonography (CEUS) in the differential diagnosis of benign, borderline ovarian tumors (BOTs), and malignant ovarian epithelial tumors (OETs).The clinical data of 108 patients who underwent surgery for pathologically confirmed of OETs at Peking University People's Hospital between December 2018 and November 2023 were retrospectively studied. The diagnostic value of 2D-US combined with CEUS for diagnosing OETs was analyzed using chi-square tests, receiver operating characteristic (ROC) curves, and random forest models.Among the 108 cases of OETs, 23 were benign, 34 were BOTs, and 51 were malignant. Chi-square tests confirmed that the perfusion pattern of the contrast agent plays an important role in the differential diagnosis of OETs. Compared with those in the benign group, the BOTs were not significantly different in terms of perfusion phase and enhancement intensity, but the regression time of the BOTs was earlier (P < 0.05). Compared with the BOTs, the malignant tumors group showed earlier perfusion and higher enhancement intensity, with no significant difference in regression time. The ROC curve results indicated that the combined diagnostic efficiency of 2D-US and CEUS in distinguishing OETs was significantly higher than that of a single diagnostic technique in terms of sensitivity, specificity, accuracy, and AUC. The random forest model results revealed that among the various parameters used in the differential diagnosis of OETs, the perfusion pattern was the most significant factor.2D-US combined with CEUS helps improve the differential diagnostic efficiency for benign, BOTs, and malignant OETs.© 2024. The Author(s).