青春期前男性接受睾丸组织冷冻（TTF）的经验和中长期男科健康随访情况如何？这项单中心纵向回顾性队列研究报告了中长期男科健康随访对 2007 年 1 月至 2018 年 12 月期间接受 TTF 保留生育能力的青春期前男性和年轻人进行健康随访。分析 TTF 后 18 个月以上收集的医疗特征和问卷数据。在医疗期间对 36 名患者进行了重新随访。后续咨询。在 TTF 后的随访过程中，72.7% 的患者无法回忆起 TTF 之前的咨询咨询，但其中 42.4% 的患者认为有关 TTF 过程的信息有用且充分。家长或法定监护人对咨询咨询和 TTF 流程的反馈更为积极。 TTF 和治疗后，提供精液样本的大多数患者 (76.9%) 患有非梗阻性无精症。与少精子症患者相比，较高的 FSH 和 LH 血清浓度以及较低的抑制素 B 血清浓度与非梗阻性无精子症相关（分别为 P=0.0182、P=0.0245 和 P=0.0140）。在癌症治疗期间，约一半的青春期患者出现性功能障碍，治疗后这一比例下降至约 20%。然而，两名患者通过捐献精子生育了孩子，一名患者通过自然怀孕生育了孩子。父母或法定监护人的参与在青春期前男孩保留生育能力的决策过程中至关重要。定期随访（包括使用调查问卷）对于为生育力保存计划提供指导、提供有关生育力恢复方案的信息以及解决生育力保存的心理社会问题至关重要。版权所有 © 2024。由 Elsevier Ltd 出版。

What is the experience and mid- and long-term andrological health follow-up of (pre)pubertal males who have undergone testicular tissue freezing (TTF)?This single-centre longitudinal retrospective cohort study reports on the mid- and long-term andrological health follow-up of (pre)pubertal males and young adults who underwent TTF for fertility preservation between January 2007 and December 2018. Medical characteristics and questionnaire data collected more than 18 months after TTF were analysed.Thirty-six patients were revisited during a medical follow-up consultation. During follow-up after TTF, 72.7% of patients could not recollect their counselling consultation prior to TTF but 42.4% of them found information about the TTF process useful and sufficient. Parents' or legal guardians' feedback was more positive about the counselling consultation and the TTF process. After TTF and treatment, the majority of patients (76.9%) who provided a semen sample had non-obstructive azoospermia. Higher serum concentrations of FSH and LH and lower serum concentrations of inhibin B were associated with non-obstructive azoospermia compared with patients with oligozoospermia (P = 0.0182, P = 0.0245 and P = 0.0140 respectively). During cancer treatment, about half of pubertal patients reported sexual dysfunction, decreasing to approximately 20% after treatment. However, two patients had children using sperm donation and one patient had a child through natural pregnancy.The involvement of parents or legal guardians is crucial in the decision-making process for fertility preservation in (pre)pubertal boys. Regular follow-up, including the use of questionnaires, is essential to provide guidance for fertility preservation programmes and information on fertility restoration options and to address the psychosocial aspects of fertility preservation.Copyright © 2024. Published by Elsevier Ltd.