利用无细胞DNA片段组和蛋白质生物标志物的卵巢癌早期检测

Early Detection of Ovarian Cancer Using Cell-Free DNA Fragmentomes and Protein Biomarkers

Cancer Discovery

影响因子:33.3

分区:医学1区 Top / 肿瘤学1区

发表日期:2025 Jan 13

作者: Jamie E Medina, Akshaya V Annapragada, Pien Lof, Sarah Short, Adrianna L Bartolomucci, Dimitrios Mathios, Shashikant Koul, Noushin Niknafs, Michaël Noë, Zachariah H Foda, Daniel C Bruhm, Carolyn Hruban, Nicholas A Vulpescu, Euihye Jung, Renu Dua, Jenna V Canzoniero, Stephen Cristiano, Vilmos Adleff, Heather Symecko, Daan van den Broek, Lori J Sokoll, Stephen B Baylin, Michael F Press, Dennis J Slamon, Gottfried E Konecny, Christina Therkildsen, Beatriz Carvalho, Gerrit A Meijer, Claus Lindbjerg Andersen, Susan M Domchek, Ronny Drapkin, Robert B Scharpf, Jillian Phallen, Christine A R Lok, Victor E Velculescu

DOI: 10.1158/2159-8290.CD-24-0393

摘要

目前亟需一种有效的卵巢癌筛查和诊断方法，以实现早期癌症检测和提高总体生存率。我们开发了一种高效且易于获取的方法，结合评估无细胞DNA片段组和蛋白质生物标志物，用于检测卵巢癌。

Abstract

There is an unmet need for effective ovarian cancer screening and diagnostic approaches that enable earlier-stage cancer detection and increased overall survival. We have developed a high-performing accessible approach that evaluates cfDNA fragmentomes and protein biomarkers to detect ovarian cancer.