纳米级的Epigallocatechin-3-Gallate：一种新的癌症治疗策略
Epigallocatechin-3-gallate at the nanoscale: a new strategy for cancer treatment
影响因子:4.80000
分区:医学3区 / 医学实验技术2区 药学2区 植物科学2区
发表日期:2024 Dec
作者:
Wenxue Sun, Yizhuang Yang, Cuiyun Wang, Mengmeng Liu, Jianhua Wang, Sen Qiao, Pei Jiang, Changgang Sun, Shulong Jiang
摘要
Epigallocatechin-3-Gallate（EGCG）是绿茶中的主要儿茶素，它通过调节多种信号通路的能力来表明对各种类型的癌细胞对抗各种类型的癌细胞的潜力。然而，其低生物利用性和快速降解阻碍了其临床应用。该评论探讨了纳米封装的潜力，以增强EGCG在癌症治疗中的稳定性，生物利用度和治疗功效。 文学。这篇评论研究了纳米工程技术的最新技术进步，这些技术将EGCG封装在各种纳米载体中。重点是评估所使用的纳米颗粒类型，它们的合成方法以及用于优化药物输送，诊断能力和治疗结果的技术。纳米颗粒改善了EGCG的物理化学稳定性和药代动力学，从而导致癌症治疗中增强的治疗方法。纳米囊化允许靶向药物输送，受控释放，增强的细胞摄取以及EGCG的过早降解。该研究强调的包括那些在各种模型中载有EGCG负载的纳米颗粒会显着抑制肿瘤的生长，从而通过主动靶向机制表现出增强的穿透力和功效。EGCG的纳米囊化代表了肿瘤学的一种有希望的方法，在其未包裹的形式中提供了多种治疗益处。尽管到目前为止的结果是有希望的，但对于充分优化这些纳米系统的设计以确保其安全性，有效性和临床生存能力是必要的进一步研究。
Abstract
Epigallocatechin-3-gallate (EGCG), the predominant catechin in green tea, has shown the potential to combat various types of cancer cells through its ability to modulate multiple signaling pathways. However, its low bioavailability and rapid degradation hinder its clinical application.This review explores the potential of nanoencapsulation to enhance the stability, bioavailability, and therapeutic efficacy of EGCG in cancer treatment.We searched the PubMed database from 2019 to the present, using 'epigallocatechin gallate', 'EGCG', and 'nanoparticles' as search terms to identify pertinent literature. This review examines recent nano-engineering technology advancements that encapsulate EGCG within various nanocarriers. The focus was on evaluating the types of nanoparticles used, their synthesis methods, and the technologies applied to optimize drug delivery, diagnostic capabilities, and therapeutic outcomes.Nanoparticles improve the physicochemical stability and pharmacokinetics of EGCG, leading to enhanced therapeutic outcomes in cancer treatment. Nanoencapsulation allows for targeted drug delivery, controlled release, enhanced cellular uptake, and reduced premature degradation of EGCG. The studies highlighted include those where EGCG-loaded nanoparticles significantly inhibited tumor growth in various models, demonstrating enhanced penetration and efficacy through active targeting mechanisms.Nanoencapsulation of EGCG represents a promising approach in oncology, offering multiple therapeutic benefits over its unencapsulated form. Although the results so far are promising, further research is necessary to fully optimize the design of these nanosystems to ensure their safety, efficacy, and clinical viability.