纳米技术在癌症的诊断和治疗中引起了广泛的关注。因此，旨在开发新型纳米材料并探索其在生物医学中的应用的研究受到越来越多的关注。本研究首次制备了Bi2S3-Au纳米团簇（Bi2S3-AuNCs）作为荧光/红外热成像引导光热疗法（PTT）。使用牛血清白蛋白 (BSA) 作为还原剂和稳定剂，通过优化 Bi3 和 Au3 的量，以简单、温和的方式实现了这一目标。所制备的具有特殊形貌的Bi2S3-AuNCs表现出高稳定性、优异的生物相容性和良好的光稳定性。除此之外，它还可以在肿瘤部位积聚并表现出相当大的荧光/红外热成像引导的 PTT。 Bi2S3-AuNCs 纳米颗粒将成像和治疗功能集成到先进的应用平台中，为构建新型纳米癌症诊断和治疗平台提供了可能。© 2024 作者。由 Elsevier B.V. 出版

Nanotechnology has attracted extensive attention in the diagnosis and treatment of cancer. Therefore, the research aimed at developing new nanomaterials and exploring their applications in biomedicine has attracted more attention. In this study, Bi2S3-Au nanoclusters (Bi2S3-AuNCs) as fluorescence/infrared thermal imaging-guided photothermal therapy (PTT) was prepared for the first time. It was achieved in a facile and mild way by optimizing the amount of Bi3+ and Au3+ using bovine serum albumin (BSA) as reducer and stabilizer. The as-prepared Bi2S3-AuNCs with special morphology showed high stability, excellent biocompatibility and good photostability. Apart from these, it also can accumulate at tumor sites and exhibit considerable fluorescence/infrared thermal imaging-guided PTT. Bi2S3-AuNCs nanoparticles integrate imaging and therapeutic functions into an advanced application platform, which provides the possibility to build a novel nano-cancer diagnosis and treatment platform.© 2024 The Authors. Published by Elsevier B.V.