肿瘤微环境，特别是缺氧特性和谷胱甘肽（GSH）过度表达，极大地抑制了癌症治疗的功效。在本文中，我们提出了由光敏剂（Ce6）和氧化铁（Fe3O4）/氧化锰（MnO2）复合纳米酶组成的磁性纳米平台（MNPT）的设计。活性氧（ROS），例如光照射产生的单线态氧（1O2）自由基和催化产生的羟基自由基（·OH），是治疗性物种。这些治疗物质通过增加氧化应激刺激细胞凋亡。这种细胞凋亡随后会触发免疫反应，结合光动力疗法和 T 细胞介导的免疫疗法来治疗癌症。此外，MNPT 可用作磁共振和荧光双模态成像中的造影剂，以提供治疗的实时跟踪和反馈。© 2023 作者。

The tumor microenvironment, particularly the hypoxic property and glutathione (GSH) overexpression, substantially inhibits the efficacy of cancer therapy. In this article, we present the design of a magnetic nanoplatform (MNPT) comprised of a photosensitizer (Ce6) and an iron oxide (Fe3O4)/manganese oxide (MnO2) composite nanozyme. Reactive oxygen species (ROS), such as singlet oxygen (1O2) radicals produced by light irradiation and hydroxyl radicals (·OH) produced by catalysis, are therapeutic species. These therapeutic substances stimulate cell apoptosis by increasing oxidative stress. This apoptosis then triggers the immunological response, which combines photodynamic therapy and T-cell-mediated immunotherapy to treat cancer. Furthermore, MNPT can be utilized as a contrast agent in magnetic resonance and fluorescence dual-modality imaging to give real-time tracking and feedback on treatment.© 2023 The Authors.