在美国，每年约有 63,000 名美国人罹患头颈癌 (HNC)。我们的研究目的是调查 HNC 幸存者的心血管并发症和发生 CVD 的危险因素。利用犹他州人口数据库，总共诊断了 1,901 名 HNC 患者，并从一般人群中确定了 7,796 名出生年份、性别和出生状态匹配的个体。使用多变量 Cox 比例风险模型。在癌症诊断后的头两年内，HNC 幸存者患心血管疾病 (CVD) 的可能性较高。基线时查尔斯顿合并症指数 (CCI) 高评分（风险比 (HR) 1.67，95% 1.28-2.17），II 期和 IV 期疾病（HR 1.80，95% 1.29-2.51），年龄 >=65 岁（HR 2.31） ，95% 1.85-2.88）、化疗（HR 1.47，95% 1.15-1.88）与 CVD 风险增加相关。与一般人群相比，HNC 幸存者更容易患心血管疾病，特别是如果他们有以下危险因素：年龄较大、II 期或 IV 期癌症、高基线 CCI 评分和化疗是发生 CVD 的危险因素。版权所有 © 2024 Elsevier Ltd。保留所有权利。

In the United States, approximately 63,000 Americans develop head and neck cancer (HNC) annually. Our study aims were to investigate cardiovascular complications and risk factors for development of CVD among HNC survivors.Utilizing the Utah Populations Database, a total of 1,901 HNC patients diagnosed and 7,796 birth year, sex, and birth state matched individuals from the general population were identified. Multivariate Cox proportional hazard models were used.Within the first two years after cancer diagnosis, HNC survivors had a higher likelihood of developing cardiovascular disease (CVD). High Charleston Comorbidity Index (CCI) score at baseline (Hazard Ratio (HR) 1.67, 95 % 1.28-2.17), stage II and IV disease (HR 1.80, 95 % 1.29-2.51), age >=65 years old (HR 2.31, 95 % 1.85-2.88), chemotherapy (HR 1.47, 95 % 1.15-1.88) were associated with increased CVD risk.Compared to the general population, HNC survivors were more likely to develop cardiovascular diseases, particularly if they had the following risk factors: older age, stage II or IV cancer, high baseline CCI score, and chemotherapy were risk factors for development of CVD.Copyright © 2024 Elsevier Ltd. All rights reserved.