基质金属蛋白酶 (MMP) 是一类多样化的蛋白酶，通过调节细胞外基质 (ECM) 成分、细胞因子和生长因子参与各种生理和病理过程。在中枢神经系统 (CNS) 中，MMP 在 CNS 发育、可塑性、修复和重组中发挥着重要作用，有助于学习、记忆和对损伤的神经免疫反应。 MMP 还与各种神经系统疾病有关，如阿尔茨海默病、帕金森病、脑动脉瘤、中风、癫痫、多发性硬化症和脑癌，表明这些蛋白酶是神经系统中的关键调节因子。此外，MMP 通过各种细胞过程的失调参与了嗜神经病毒感染的发病机制，这可能突显这些因素作为治疗和控制与病毒病原体相关的神经系统并发症的潜在靶点。本综述概述了 MMP 在 CNS 各种生理过程中的作用及其与嗜神经病毒病原体的相互作用。© 2024 John Wiley

Matrix metalloproteinases (MMPs) are a diverse group of proteases involved in various physiological and pathological processes through modulation of extracellular matrix (ECM) components, cytokines, and growth factors. In the central nervous system (CNS), MMPs play a major role in CNS development, plasticity, repair, and reorganisation contributing to learning, memory, and neuroimmune response to injury. MMPs are also linked to various neurological disorders such as Alzheimer's disease, Parkinson's disease, cerebral aneurysm, stroke, epilepsy, multiple sclerosis, and brain cancer suggesting these proteases as key regulatory factors in the nervous system. Moreover, MMPs have been involved in the pathogenesis of neurotropic viral infections via dysregulation of various cellular processes, which may highlight these factors as potential targets for the treatment and control of neurological complications associated with viral pathogens. This review provides an overview of the roles of MMPs in various physiological processes of the CNS and their interactions with neurotropic viral pathogens.© 2024 John Wiley & Sons Ltd.