微生物吲哚代谢物在肿瘤中的作用
The role of microbial indole metabolites in tumor
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影响因子:11
分区:医学1区 Top / 微生物学1区 胃肠肝病学2区
发表日期:2024
作者:
Dingjiacheng Jia, Zheng Kuang, Liangjing Wang
DOI:
10.1080/19490976.2024.2409209
摘要
肠道微生物群可以产生多种微生物源性代谢物，影响肿瘤的发展。色氨酸是人体必需的氨基酸，可以通过微生物的吲哚途径转化为吲哚代谢物，如吲哚-3-乳酸（ILA）、吲哚-3-丙酸（IPA）、吲哚-3-乙酸（IAA）和吲哚-3-醛（IAld）。最新研究表明，吲哚代谢物在肿瘤进展中发挥关键作用，可作为肿瘤免疫治疗或化疗的辅助方案。本文总结了常见微生物吲哚代谢物的最新研究进展，并回顾了不同吲哚代谢物在肿瘤微环境中的作用机制。我们还讨论了当前吲哚代谢物研究的局限性及未来的研究方向。预期微生物吲哚代谢物将为临床治疗提供新的策略。
Abstract
The gut microbiota can produce a variety of microbial-derived metabolites to influence tumor development. Tryptophan, an essential amino acid in the human body, can be converted by microorganisms via the indole pathway to indole metabolites such as Indole-3-Lactic Acid (ILA), Indole-3-Propionic Acid (IPA), Indole Acetic Acid (IAA) and Indole-3-Aldehyde (IAld). Recent studies have shown that indole metabolites play key roles in tumor progression, and they can be used as adjuvant regimens for tumor immunotherapy or chemotherapy. Here, we summarize recent findings on the common microbial indole metabolites and provide a review of the mechanisms of different indole metabolites in the tumor microenvironment. We further discuss the limitations of current indole metabolite research and future possibilities. It is expected that microbial indole metabolites will provide new strategies for clinical therapy.