微生物吲哚代谢物在肿瘤中的作用
The role of microbial indole metabolites in tumor
影响因子:11.00000
分区:医学1区 Top / 微生物学1区 胃肠肝病学2区
发表日期:2024
作者:
Dingjiacheng Jia, Zheng Kuang, Liangjing Wang
摘要
肠道微生物群可以产生各种微生物衍生的代谢产物来影响肿瘤的发展。色氨酸是人体中必不可少的氨基酸，可以通过微生物通过吲哚途径转化为吲哚代谢产物，例如吲哚-3-乳酸（ILA），吲哚-3-丙酸（IPA），吲哚-3-乙酸乙酸（IAA）和Indole-3-3-甲基甲羟基甲羟基（IA）。最近的研究表明，吲哚代谢产物在肿瘤进展中起关键作用，并且可以用作肿瘤免疫疗法或化学疗法的辅助方案。在这里，我们总结了关于常见微生物吲哚代谢产物的最新发现，并回顾了肿瘤微环境中不同吲哚代谢产物的机制。我们进一步讨论当前吲哚代谢物研究和未来可能性的局限性。预计微生物吲哚代谢物将为临床治疗提供新的策略。
Abstract
The gut microbiota can produce a variety of microbial-derived metabolites to influence tumor development. Tryptophan, an essential amino acid in the human body, can be converted by microorganisms via the indole pathway to indole metabolites such as Indole-3-Lactic Acid (ILA), Indole-3-Propionic Acid (IPA), Indole Acetic Acid (IAA) and Indole-3-Aldehyde (IAld). Recent studies have shown that indole metabolites play key roles in tumor progression, and they can be used as adjuvant regimens for tumor immunotherapy or chemotherapy. Here, we summarize recent findings on the common microbial indole metabolites and provide a review of the mechanisms of different indole metabolites in the tumor microenvironment. We further discuss the limitations of current indole metabolite research and future possibilities. It is expected that microbial indole metabolites will provide new strategies for clinical therapy.