肠道微生物群可以产生多种微生物衍生的代谢物来影响肿瘤的发展。色氨酸是人体必需的氨基酸，可被微生物通过吲哚途径转化为吲哚代谢物，如3-吲哚乳酸（ILA）、3-吲哚丙酸（IPA）、吲哚乙酸（IAA）等。 ）和吲哚-3-醛（IAld）。最近的研究表明，吲哚代谢物在肿瘤进展中发挥关键作用，可作为肿瘤免疫治疗或化疗的辅助方案。在这里，我们总结了常见微生物吲哚代谢物的最新发现，并对不同吲哚代谢物在肿瘤微环境中的作用机制进行了综述。我们进一步讨论当前吲哚代谢物研究的局限性和未来的可能性。预计微生物吲哚代谢产物将为临床治疗提供新策略。

The gut microbiota can produce a variety of microbial-derived metabolites to influence tumor development. Tryptophan, an essential amino acid in the human body, can be converted by microorganisms via the indole pathway to indole metabolites such as Indole-3-Lactic Acid (ILA), Indole-3-Propionic Acid (IPA), Indole Acetic Acid (IAA) and Indole-3-Aldehyde (IAld). Recent studies have shown that indole metabolites play key roles in tumor progression, and they can be used as adjuvant regimens for tumor immunotherapy or chemotherapy. Here, we summarize recent findings on the common microbial indole metabolites and provide a review of the mechanisms of different indole metabolites in the tumor microenvironment. We further discuss the limitations of current indole metabolite research and future possibilities. It is expected that microbial indole metabolites will provide new strategies for clinical therapy.