非编码RNA作为三阴性乳腺癌放射反应调节因子：系统综述
Non-coding RNAs as modulators of radioresponse in triple-negative breast cancer: a systematic review
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影响因子:12.1
分区:医学1区 Top / 医学：研究与实验1区 细胞生物学2区
发表日期:2024 Oct 02
作者:
Maria Vitoria Tofolo, Fernanda Costa Brandão Berti, Emanuelle Nunes-Souza, Mayara Oliveira Ruthes, Lucas Freitas Berti, Aline Simoneti Fonseca, Daiane Rosolen, Luciane Regina Cavalli
DOI:
10.1186/s12929-024-01081-y
摘要
三阴性乳腺癌（TNBC）以高度侵袭性为特征，其预后较差，死亡率较高。尽管已开发出有效的治疗靶点，系统性化疗和放疗（RdT）仍是主要治疗方式。放疗的一个显著挑战是获得放射抗性，这成为实现最佳治疗反应的重大障碍。大量证据表明，非编码RNA（ncRNAs）作为基因表达调控因子，在放射抗性的发展中发挥重要作用。本系统综述旨在描述ncRNAs在调节TNBC放射反应中的作用、关联和/或参与机制。遵循PRISMA指南，采用精心筛选的检索词，在四个数据库中进行全面搜索。经过基于预设纳入和排除标准的评估，筛选出至2023年10月发表的37篇原创研究文章。共识别出33种不同的ncRNAs，包括lncRNAs、miRNAs和circRNAs，它们通过调控细胞死亡和DNA损伤修复等多种分子机制影响辐射反应。本文强调了ncRNAs在调节TNBC放射敏感性中的关键作用及其复杂网络，为早期识别放射反应不佳者及易产生放射抗性的患者提供潜在途径，最终有助于改善TNBC的生存预后。
Abstract
Triple-negative breast cancer (TNBC), characterized by high invasiveness, is associated with poor prognosis and elevated mortality rates. Despite the development of effective therapeutic targets for TNBC, systemic chemotherapy and radiotherapy (RdT) remain prevalent treatment modalities. One notable challenge of RdT is the acquisition of radioresistance, which poses a significant obstacle in achieving optimal treatment response. Compelling evidence implicates non-coding RNAs (ncRNAs), gene expression regulators, in the development of radioresistance. This systematic review focuses on describing the role, association, and/or involvement of ncRNAs in modulating radioresponse in TNBC. In adhrence to the PRISMA guidelines, an extensive and comprehensive search was conducted across four databases using carefully selected entry terms. Following the evaluation of the studies based on predefined inclusion and exclusion criteria, a refined selection of 37 original research articles published up to October 2023 was obtained. In total, 33 different ncRNAs, including lncRNAs, miRNAs, and circRNAs, were identified to be associated with radiation response impacting diverse molecular mechanisms, primarily the regulation of cell death and DNA damage repair. The findings highlighted in this review demonstrate the critical roles and the intricate network of ncRNAs that significantly modulates TNBC's responsiveness to radiation. The understanding of these underlying mechanisms offers potential for the early identification of non-responders and patients prone to radioresistance during RdT, ultimately improving TNBC survival outcomes.