非编码RNA作为三阴性乳腺癌中辐射响应的调节剂：系统评价
Non-coding RNAs as modulators of radioresponse in triple-negative breast cancer: a systematic review
影响因子:12.10000
分区:医学1区 Top / 医学：研究与实验1区 细胞生物学2区
发表日期:2024 Oct 02
作者:
Maria Vitoria Tofolo, Fernanda Costa Brandão Berti, Emanuelle Nunes-Souza, Mayara Oliveira Ruthes, Lucas Freitas Berti, Aline Simoneti Fonseca, Daiane Rosolen, Luciane Regina Cavalli
摘要
以高侵入性为特征的三阴性乳腺癌（TNBC）与预后不良和死亡率升高有关。尽管开发了有效的TNBC治疗靶标，但全身化疗和放疗（RDT）仍然是普遍的治疗方式。 RDT的一个值得注意的挑战是对放射线的获取，这在实现最佳治疗反应方面构成了重要障碍。令人信服的证据暗示非编码RNA（NCRNA），基因表达调节剂，在辐射势的发展中。这项系统评价的重点是描述NCRNA在调节TNBC中调节辐射响应中的作用，关联和/或参与。为了遵守PRISMA指南，使用精心选择的输入条款在四个数据库中进行了广泛而全面的搜索。根据根据预定义的纳入和排除标准评估研究后，获得了截至2023年10月的37个原始研究文章的精致选择。总共确定33种不同的NCRNA，包括LNCRNA，miRNA和CIRCRNA，与辐射反应有关，影响分子机制的不同，主要是对细胞死亡和DNA损伤修复的调节。这篇综述中强调的发现证明了NCRNA的关键作用和复杂的网络，这些网络显着调节了TNBC对辐射的响应能力。对这些潜在机制的理解为早期鉴定RDT期间不反应和患者易于放射线的患者提供了潜力，最终改善了TNBC的生存结果。
Abstract
Triple-negative breast cancer (TNBC), characterized by high invasiveness, is associated with poor prognosis and elevated mortality rates. Despite the development of effective therapeutic targets for TNBC, systemic chemotherapy and radiotherapy (RdT) remain prevalent treatment modalities. One notable challenge of RdT is the acquisition of radioresistance, which poses a significant obstacle in achieving optimal treatment response. Compelling evidence implicates non-coding RNAs (ncRNAs), gene expression regulators, in the development of radioresistance. This systematic review focuses on describing the role, association, and/or involvement of ncRNAs in modulating radioresponse in TNBC. In adhrence to the PRISMA guidelines, an extensive and comprehensive search was conducted across four databases using carefully selected entry terms. Following the evaluation of the studies based on predefined inclusion and exclusion criteria, a refined selection of 37 original research articles published up to October 2023 was obtained. In total, 33 different ncRNAs, including lncRNAs, miRNAs, and circRNAs, were identified to be associated with radiation response impacting diverse molecular mechanisms, primarily the regulation of cell death and DNA damage repair. The findings highlighted in this review demonstrate the critical roles and the intricate network of ncRNAs that significantly modulates TNBC's responsiveness to radiation. The understanding of these underlying mechanisms offers potential for the early identification of non-responders and patients prone to radioresistance during RdT, ultimately improving TNBC survival outcomes.