肝癌、胆道癌和胰腺癌因其高度恶性而对消化系统疾病领域提出了重大挑战。中医药（TCM）作为一种潜在的治疗方法而受到关注，在中国长期使用且临床疗效得到公认。在这篇综述中，我们系统地总结了中医药在治疗肝癌、胆道癌和胰腺癌的临床试验中显示出的良好效果的临床应用。我们重点介绍了几种经过严格临床试验验证疗效的常用中药疗法，包括槐耳颗粒、花蟾素和淫羊藿素。活性化合物及其潜在靶点已得到彻底阐明，为中药抗癌药物发现的潜力提供了宝贵的见解。我们强调进一步研究的重要性，以弥合中医与现代肿瘤学之间的差距，促进针对这些具有挑战性的恶性肿瘤的循证中医治疗的发展。© 2024。作者。

Hepatic, biliary, and pancreatic cancer pose significant challenges in the field of digestive system diseases due to their highly malignant nature. Traditional Chinese medicine (TCM) has gained attention as a potential therapeutic approach with long-standing use in China and well-recognized clinical benefits. In this review, we systematically summarized the clinical applications of TCM that have shown promising results in clinical trials in treating hepatic, biliary, and pancreatic cancer. We highlighted several commonly used TCM therapeutics with validated efficacy through rigorous clinical trials, including Huaier Granule, Huachansu, and Icaritin. The active compounds and their potential targets have been thoroughly elucidated to offer valuable insights into the potential of TCM for anti-cancer drug discovery. We emphasized the importance of further research to bridge the gap between TCM and modern oncology, facilitating the development of evidence-based TCM treatment for these challenging malignancies.© 2024. The Author(s).