肝窦主要由肝窦内皮细胞、肝巨噬细胞和肝星状细胞组成，塑造肝血管系统，是维持肝脏稳态和功能的关键。慢性肝病（CLD）时，肝窦细胞功能受损，直接参与肝纤维化、肝硬化以及门脉高压、肝细胞癌等主要临床并发症的进展。除了在肝脏疾病病理学中的作用之外，正弦细胞的旁分泌通讯或串扰正在作为疾病机制进行研究，同时也是一个显着的治疗目标。本综述的目的是收集肝病进展过程中肝窦细胞间信号传导的最新知识。我们总结了 CLD 临床前模型中开展的研究，特别强调了以人为基础的临床相关模型中所表征的那些途径。最后，我们将针对正弦通讯的药物治疗描述为治疗慢性肺病及其临床并发症的有希望的选择。

The liver sinusoid, mainly composed of liver sinusoidal endothelial cells, hepatic macrophages and hepatic stellate cells, shapes the hepatic vasculature and is key maintaining liver homeostasis and function. During chronic liver disease (CLD), the function of sinusoidal cells is impaired, being directly involved in the progression of liver fibrosis, cirrhosis, and main clinical complications including portal hypertension and hepatocellular carcinoma. In addition to their roles in liver diseases pathobiology, sinusoidal cells' paracrine communication or cross-talk is being studied as a mechanism of disease but also as a remarkable target for treatment. The aim of this review is to gather current knowledge of intercellular signalling in the hepatic sinusoid during the progression of liver disease. We summarise studies developed in pre-clinical models of CLD, specially emphasizing those pathways characterized in human-based clinically relevant models. Finally, we describe pharmacological treatments targeting sinusoidal communication as promising options to treat CLD and its clinical complications.