确定与非癌症患者相比，癌症患者在急诊普通外科 (EGS) 病症的发生率或管理方面是否存在差异。癌症患者中 EGS 病症的真实频率和自然史尚未得到表征。我们利用了 SEER-Medicare 数据2006 年 1 月至 2015 年 12 月期间，将乳腺癌、前列腺癌和肺癌患者与非癌症患者进行比较。从癌症诊断日期或非癌症患者的索引日期开始对患者进行随访，直至出现 EGS 病症、死亡或最后一次随访。我们评估了 EGS 状况随时间的累积发生率，并拟合多变量 Cox 比例风险模型来评估时间依赖性手术干预对死亡率的影响。我们确定了 322,756 名患有乳腺癌 (N=82,147)、肺部 (N=128,618)、前列腺癌 (N=111,991) 和 210,429 名非癌症患者。癌症患者在诊断后第一年内 EGS 病症的发生率较高（4.8% vs. 3.2%），其中肺癌（6.8%）和乳腺癌(4.0%) 显示一致的撕裂。癌症患者接受手术的可能性较小（13% vs. 14%，P=0.005），尽管这因癌症类型和 EGS 状况而异。乳腺癌（HR 1.27，95%CI 1.17-1.39）和肺癌（HR 3.27，95%CI 3.07-3.48）患者在 EGS 诊断后 30 天内死亡的可能性更大。癌症患者 EGS 发生率更高诊断后第一年内出现病情，但不太可能接受手术。未来的研究需要探索 EGS 状况、其管理、接受预期肿瘤治疗以及由此产生的结果之间的相互作用。版权所有 © 2024 Wolters Kluwer Health, Inc. 保留所有权利。

To determine if cancer patients experience variability in incidence or management of emergency general surgery (EGS) conditions compared to non-cancer patients.The true frequency, and natural history of EGS conditions among cancer patients has not been characterized.We utilized SEER-Medicare data from January 2006-December 2015 to compare patients with breast, prostate, and lung cancer to a non-cancer cohort. Patients were followed from date of cancer diagnosis, or an index date for non-cancer patients, to the development of an EGS condition, death or last follow up. We assessed the cumulative incidence of EGS conditions over time, and fit multivariable Cox proportional hazards models to evaluate the impact of time-dependent surgical intervention on mortality.We identified 322,756 patients with breast (N=82,147), lung (N=128,618), and prostate cancer (N=111,991) and 210,429 non-cancer patients.. Cancer patients had a higher incidence of an EGS condition within the first year after diagnosis (4.8% vs. 3.2%), with lung (6.8%) and breast cancer (4.0%) showing consistent rends. Cancer patients were less likely to undergo surgery for (13% vs. 14%, P=0.005), though this varied by cancer type and EGS conditions. Patients with breast (HR 1.27, 95%CI 1.17-1.39) and lung cancer (HR 3.27, 95%CI 3.07-3.48) were more likely to die within 30-days of an EGS diagnosis.Cancer patients experience a higher incidence of EGS conditions within the first year following diagnosis, but are less likely to undergo surgery. Future research is needed to explore the interplay between EGS conditions, their management, and receipt of intended oncologic therapy, and resulting outcomes.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.