Maydisens，来自玉米双极菌的具有抗 MDR 活性的二元萜类化合物。
Maydisens, Sesterterpenoids with Anti-MDR Activity from Bipolaris maydis.
发表日期：2024 Oct 02
作者：
Yong Shen, Nanjin Ding, Lianghu Gu, Mengru Yu, Qin Li, Weiguang Sun, Chunmei Chen, Yonghui Zhang, Hucheng Zhu
来源：
JOURNAL OF NATURAL PRODUCTS
摘要：
从玉米扁豆中分离出 14 种先前未描述的二元萜类化合物 (1-14)。通过NMR、HRESIMS、DP4计算、ECD计算、单晶X射线衍射分析和改进的Mosher方法阐明了它们的绝对构型结构。化合物1-5具有首次从玉米芽孢杆菌中鉴定出的不常见的5/11双环系统。化合物6-14具有5/8/5三环系统，并且这些化合物在环A中均具有羰基。化合物10显示出显着逆转癌细胞中的紫杉醇耐药性。
Fourteen previously undescribed sesterterpenoids (1-14) were isolated from Bipolaris maydis. Their structures with absolute configurations were elucidated by NMR, HRESIMS, DP4+ calculations, ECD calculations, single-crystal X-ray diffraction analyses, and the modified Mosher's method. Compounds 1-5 possess an uncommon 5/11 bicyclic ring system identified from B. maydis for the first time. Compounds 6-14 have a 5/8/5 tricyclic ring system, and these compounds both possess carbonyl groups in ring A. Compound 10 showed significant reversal of paclitaxel resistance in cancer cells.