治愈时间：抑制纤维化可防止胶质母细胞瘤复发。
Time to heal: inhibiting fibrosis prevents glioblastoma recurrence.
发表日期：2024 Oct 01
作者：
Dhanashree Mundhe, Neta Erez
来源：
Trends in Cancer
摘要：
沃森等人的新发现。证明治疗引起的炎症和纤维化会加剧胶质母细胞瘤的复发。治疗后纤维化微环境保护存活的肿瘤细胞免受免疫监视，支持它们持续处于休眠状态，并实现反弹生长。及时抑制炎症和疤痕可减轻复发，鼓励在胶质母细胞瘤治疗中使用新的组合方法。版权所有 © 2024 Elsevier Inc. 保留所有权利。
New findings by Watson et al. demonstrate that therapy-induced inflammation and fibrosis potentiate glioblastoma recurrence. Post-treatment fibrotic niches shielded surviving tumor cells from immune surveillance, supported their persistence in a dormant state, and enabled rebound growth. Timely inhibition of inflammation and scarring attenuated recurrence, encouraging the use of new combinatorial approaches in glioblastoma therapy.Copyright © 2024 Elsevier Inc. All rights reserved.