计算机和临床中罕见癌症突变的中性进化。
Neutral evolution of rare cancer mutations in the computer and the clinic.
发表日期：2024 Oct 02
作者：
Robert A Beckman
来源：
npj Systems Biology and Applications
摘要：
描述了罕见癌症突变的中性进化的独特模型，并将其与依赖于无限位点近似的模型（即在任何时刻仅在一个细胞中出现特定突变）进行对比。临床细胞数量预计会出现遗传多样性的爆炸性增长，这可能解释了癌症在临床过程中逐渐难治的情况。广泛使用的无限位点假设可能不适用于临床癌症。© 2024。作者。
A distinct model of neutral evolution of rare cancer mutations is described and contrasted with models relying on the infinite sites approximation (that a specific mutation arises in only one cell at any instant). An explosion of genetic diversity is predicted at clinical cell numbers and may explain the progressive refractoriness of cancers during a clinical course. The widely used infinite sites assumption may not be applicable for clinical cancers.© 2024. The Author(s).