内脏肥胖指数（VAI）是内脏脂肪堆积和代谢功能障碍的标志，但其与癌症相关的证据有限。本研究的目的是调查 VAI 与 23 个地点的癌症发生和全因癌症之间的关联。 总共有 385,477 名来自英国生物银行前瞻性队列的参与者（53.3% 为女性；平均年龄为 56.3 岁）纳入研究这项研究。中位随访时间为 8.2 年（四分位数范围，7.3-8.9 年）。 VAI 使用 Amato 等人发布的公式计算。并被分类为特定性别的三分位数。结果是二十四例癌症。 Cox 比例风险模型根据社会人口统计学、生活方式因素和多重发病计数进行了调整。在随访期间，有 47,882 人患上了癌症。在完全调整的模型中，VAI 与六个癌症部位的较高风险相关。与最低三分位数的个体相比，最高三分位数的个体具有更高的子宫风险（风险比 [HR]，2.09；95% 置信区间 [CI]，1.76-2.49）、胆囊风险（HR，1.83；95% CI） ，1.26-2.66）、肾脏（HR，1.39；95% CI，1.18-1.64）、肝脏（HR，1.25；95% CI，1.00-1.56）、结直肠（HR，1.14；95% CI，1.05-1.24） 、乳腺癌（HR，1.11；95% CI，1.03-1.19）和全因癌症（HR，1.05）。没有证据表明 VAI 与癌症风险之间存在非线性关联。VAI 与六个癌症部位以及全因癌症相关。内脏脂肪积累和功能障碍在癌症中的预后和病因作用值得进一步研究。© 2024 作者。 《癌症》由 Wiley periodicals LLC 代表美国癌症协会出版。

The visceral adiposity index (VAI) is a marker of visceral fat accumulation and metabolic dysfunction, but there is limited evidence of its association with cancer. The objective of this study was to investigate associations between the VAI and both incident cancer at 23 sites and all-cause cancer.In total, 385,477 participants (53.3% women; mean age, 56.3 years) from the UK Biobank prospective cohort were included in this study. The median follow-up was 8.2 years (interquartile range, 7.3-8.9 years). The VAI was calculated using formula the published by Amato et al. and was categorized into sex-specific tertiles. Twenty-four incident cancers were the outcomes. Cox proportional hazard models were adjusted for sociodemographics, lifestyle factors, and multimorbidity counts.Over the follow-up period, 47,882 individuals developed cancer. In the fully adjusted models, the VAI was associated with a higher risk of six cancer sites. Individuals in the highest tertile, compared with those in the lowest tertile, had higher risks of uterine (hazard ratio [HR], 2.09; 95% confidence interval [CI], 1.76-2.49), gallbladder (HR, 1.83; 95% CI, 1.26-2.66), kidney (HR, 1.39; 95% CI, 1.18-1.64), liver (HR, 1.25; 95% CI, 1.00-1.56), colorectal (HR, 1.14; 95% CI, 1.05-1.24), and breast (HR, 1.11; 95% CI, 1.03-1.19) cancers and of all-cause cancer (HR, 1.05). There was no evidence of a nonlinear association between the VAI and cancer risk.The VAI was associated with six cancer sites and with all-cause cancer. The prognostic and etiologic roles of visceral fat accumulation and dysfunction in cancer warrant further research.© 2024 The Author(s). Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.