英国生物库队列中内脏脂肪指数与癌症风险的关联性研究

Association between visceral adiposity index and cancer risk in the UK Biobank cohort

CANCER

影响因子:5.1

分区:医学1区 Top / 肿瘤学2区

发表日期:2025 Jan 01

作者: Solange Parra-Soto, Jirapitcha Boonpor, Nathan Lynskey, Carolina Araya, Frederick Ho, Jill P Pell, Carlos Celis-Morales

DOI: 10.1002/cncr.35576

摘要

内脏脂肪指数（VAI）是内脏脂肪积累及代谢功能障碍的标志，但关于其与癌症的关联证据有限。本研究旨在探讨VAI与23个部位的癌症新发及全因癌症的关系。共纳入英国生物库前瞻性队列中的385,477名参与者（女性占53.3%；平均年龄56.3岁）。随访中位数为8.2年（四分位间距7.3-8.9年）。VAI根据Amato等人公布的公式计算，按性别特异性三分组。研究的结局包括24种新发癌症。采用调整社会人口学、生活方式因素和多发病计数的Cox比例风险模型。在随访期间，有47,882人发生癌症。在完全调整模型中，VAI与六个癌症部位的风险升高相关。最高三分组的个体与最低三分组相比，子宫（HR=2.09，95% CI=1.76-2.49）、胆囊（HR=1.83，95% CI=1.26-2.66）、肾脏（HR=1.39，95% CI=1.18-1.64）、肝脏（HR=1.25，95% CI=1.00-1.56）、结直肠（HR=1.14，95% CI=1.05-1.24）及乳腺癌（HR=1.11，95% CI=1.03-1.19）以及全因癌症（HR=1.05）风险均显著升高。VAI与癌症风险之间未观察到非线性关系。VAI与六个癌症部位及全因癌症的风险相关，脂肪积聚及功能障碍在癌症中的作用值得进一步研究。

Abstract

The visceral adiposity index (VAI) is a marker of visceral fat accumulation and metabolic dysfunction, but there is limited evidence of its association with cancer. The objective of this study was to investigate associations between the VAI and both incident cancer at 23 sites and all-cause cancer.In total, 385,477 participants (53.3% women; mean age, 56.3 years) from the UK Biobank prospective cohort were included in this study. The median follow-up was 8.2 years (interquartile range, 7.3-8.9 years). The VAI was calculated using formula the published by Amato et al. and was categorized into sex-specific tertiles. Twenty-four incident cancers were the outcomes. Cox proportional hazard models were adjusted for sociodemographics, lifestyle factors, and multimorbidity counts.Over the follow-up period, 47,882 individuals developed cancer. In the fully adjusted models, the VAI was associated with a higher risk of six cancer sites. Individuals in the highest tertile, compared with those in the lowest tertile, had higher risks of uterine (hazard ratio [HR], 2.09; 95% confidence interval [CI], 1.76-2.49), gallbladder (HR, 1.83; 95% CI, 1.26-2.66), kidney (HR, 1.39; 95% CI, 1.18-1.64), liver (HR, 1.25; 95% CI, 1.00-1.56), colorectal (HR, 1.14; 95% CI, 1.05-1.24), and breast (HR, 1.11; 95% CI, 1.03-1.19) cancers and of all-cause cancer (HR, 1.05). There was no evidence of a nonlinear association between the VAI and cancer risk.The VAI was associated with six cancer sites and with all-cause cancer. The prognostic and etiologic roles of visceral fat accumulation and dysfunction in cancer warrant further research.