英国生物库队列的内脏肥胖指数与癌症风险之间的关联
Association between visceral adiposity index and cancer risk in the UK Biobank cohort
影响因子:5.10000
分区:医学1区 Top / 肿瘤学2区
发表日期:2025 Jan 01
作者:
Solange Parra-Soto, Jirapitcha Boonpor, Nathan Lynskey, Carolina Araya, Frederick Ho, Jill P Pell, Carlos Celis-Morales
摘要
内脏肥胖指数（VAI）是内脏脂肪积累和代谢功能障碍的标志，但证据表明其与癌症的关系有限。这项研究的目的是研究VAI与23个部位和全因癌症的VAI与入射癌之间的关联。总共包括385,477名参与者（53.3％的女性；平均年龄为56.3岁，56.3岁），包括在本研究中。中位随访时间为8。2年（四分位数范围为7。3-8.9岁）。使用公式计算VAI，由Amato等人发布。并被归类为性别特定的三物种。二十四个事件癌症是结果。调整了COX比例危害模型，以针对社会人口统计学，生活方式因素和多种危险计数进行调整。在后续时期，有47,882个人患有癌症。在完全调整的模型中，VAI与六个癌症部位的风险更高有关。 Individuals in the highest tertile, compared with those in the lowest tertile, had higher risks of uterine (hazard ratio [HR], 2.09; 95% confidence interval [CI], 1.76-2.49), gallbladder (HR, 1.83; 95% CI, 1.26-2.66), kidney (HR, 1.39; 95% CI, 1.18-1.64), liver （HR，1.25; 95％CI，1.00-1.56），结直肠（HR，1.14; 95％CI，1.05-1.24）和乳房（HR，1.11; 95％CI，1.03-1.19）癌症和所有因素癌（HR，HR，1.05）。没有证据表明VAI和癌症风险之间存在非线性关联。VAI与六个癌症部位和全因癌症有关。内脏脂肪积累和功能障碍在癌症中的预后和病因作用需要进一步研究。
Abstract
The visceral adiposity index (VAI) is a marker of visceral fat accumulation and metabolic dysfunction, but there is limited evidence of its association with cancer. The objective of this study was to investigate associations between the VAI and both incident cancer at 23 sites and all-cause cancer.In total, 385,477 participants (53.3% women; mean age, 56.3 years) from the UK Biobank prospective cohort were included in this study. The median follow-up was 8.2 years (interquartile range, 7.3-8.9 years). The VAI was calculated using formula the published by Amato et al. and was categorized into sex-specific tertiles. Twenty-four incident cancers were the outcomes. Cox proportional hazard models were adjusted for sociodemographics, lifestyle factors, and multimorbidity counts.Over the follow-up period, 47,882 individuals developed cancer. In the fully adjusted models, the VAI was associated with a higher risk of six cancer sites. Individuals in the highest tertile, compared with those in the lowest tertile, had higher risks of uterine (hazard ratio [HR], 2.09; 95% confidence interval [CI], 1.76-2.49), gallbladder (HR, 1.83; 95% CI, 1.26-2.66), kidney (HR, 1.39; 95% CI, 1.18-1.64), liver (HR, 1.25; 95% CI, 1.00-1.56), colorectal (HR, 1.14; 95% CI, 1.05-1.24), and breast (HR, 1.11; 95% CI, 1.03-1.19) cancers and of all-cause cancer (HR, 1.05). There was no evidence of a nonlinear association between the VAI and cancer risk.The VAI was associated with six cancer sites and with all-cause cancer. The prognostic and etiologic roles of visceral fat accumulation and dysfunction in cancer warrant further research.