口腔健康相关生活质量在口咽癌幸存者中的研究

Oral health-related quality of life among oropharyngeal cancer survivors

ORAL ONCOLOGY

影响因子:3.9

分区:医学2区 / 牙科与口腔外科2区肿瘤学3区

发表日期:2024 Dec

作者: Alzina Koric, Chun-Pin Chang, Siqi Hu, John Snyder, Vikrant G Deshmukh, Michael G Newman, Ankita P Date, Marcus M Monroe, Mia Hashibe

DOI: 10.1016/j.oraloncology.2024.107062

摘要

随着美国口咽癌发病率的持续上升，关于口咽癌患者生活质量（QoL）的研究仍然有限。本试点研究的目标是评估口腔健康对口咽癌幸存者生活质量的影响。从1996年至2016年确诊癌症的口咽癌幸存者中抽样，来源于犹他州癌症登记处。2019年1月至5月期间，采用口腔健康影响评估问卷-14（OHIP-14）调查问卷，对受试者进行评估。通过简单线性回归分析（β系数）评估口腔健康对生活质量的影响。在260名口咽癌幸存者中，大部分为男性（84.6%），在癌症诊断时年龄≥60岁（74.0%）。OHIP-14中最常报告的不适症状为进食任何食物时的不适（19.2%）和味觉减退（16.0%）。整体OHIP-14平均得分为13.3。女性（β=12.85，p=0.01）、接受化疗的患者（β=6.60，p=0.02）以及曾经吸烟者（β=5.25，p=0.04）表现出明显较差的生活质量。相反，远期癌症分期（β=-7.66，p=0.01）、较高收入（β=-2.50，p=0.05）以及诊断年龄较大（β=-0.35，p=0.03）与较好的口腔相关生活质量相关。该试点研究中观察到的口腔健康相关生活质量评分提示，患者症状管理仍有提升空间，需持续改善。

Abstract

The incidence of oropharyngeal cancer continues to rise in the United States, yet studies on the quality of life (QoL) of oropharyngeal cancer patients are limited. The objective of this pilot study was to assess the impact of oral health on the QoL in oropharyngeal cancer survivors.Oropharyngeal cancer survivors with a confirmed cancer diagnosis from 1996 to 2016 were sampled from the Utah Cancer Registry. The Oral Health Impact Profile-14 (OHIP-14) questionnaire was administrated between January and May of 2019. The impact of oral health on QoL was evaluated using simple linear regression (β-coefficient).Among the 260 oropharyngeal cancer survivors, the majority were male (84.6 %) and ≥ 60 years of age at the time of cancer diagnosis (74.0 %). The most frequently reported symptoms of OHIP-14 were discomfort while eating any foods (19.2 %) and worsening sense of taste (16.0 %). The overall OHIP-14 mean score was 13.3. Significantly worse OHIP-14 scores were observed for females (β = 12.85, p = 0.01), chemotherapy recipients (β = 6.60, p = 0.02), and past smokers (β = 5.25, p = 0.04). Better OHIP-14 scores (better oral QoL) were observed in patients with distant cancer stage (β = -7.66, p = 0.01), higher income (β = -2.50, p = 0.05), and older age at cancer diagnosis (β = -0.35, p = 0.03).The oral health-related quality of life scores observed in this pilot study suggest a need for improvement in patient symptom management over time.