在美国，口咽癌的发病率持续上升，但有关口咽癌患者生活质量（QoL）的研究却很有限。这项试点研究的目的是评估口腔健康对口咽癌幸存者生活质量的影响。从 1996 年至 2016 年确诊癌症的口咽癌幸存者样本来自犹他州癌症登记处。口腔健康影响概况-14 (OHIP-14) 调查问卷于 2019 年 1 月至 5 月期间进行。使用简单线性回归（β 系数）评估口腔健康对生活质量的影响。在 260 名口咽癌幸存者中，大多数为男性 (84.6 %)，癌症诊断时年龄≥ 60 岁 (74.0 %)。最常报告的 OHIP-14 症状是吃任何食物时感到不适 (19.2%) 和味觉恶化 (16.0%)。 OHIP-14 的总体平均分为 13.3。观察到女性（β = 12.85，p = 0.01）、化疗接受者（β = 6.60，p = 0.02）和既往吸烟者（β = 5.25，p = 0.04）的 OHIP-14 评分显着较差。癌症分期较远 (β = -7.66, p = 0.01)、收入较高 (β = -2.50, p = 0.05) 和癌症诊断年龄较高 (β = -7.66, p = 0.01) 的患者观察到更好的 OHIP-14 评分（更好的口腔生活质量） = -0.35，p = 0.03)。在这项试点研究中观察到的口腔健康相关生活质量评分表明，随着时间的推移，需要改进患者症状管理。版权所有 © 2024。由 Elsevier Ltd 出版。

The incidence of oropharyngeal cancer continues to rise in the United States, yet studies on the quality of life (QoL) of oropharyngeal cancer patients are limited. The objective of this pilot study was to assess the impact of oral health on the QoL in oropharyngeal cancer survivors.Oropharyngeal cancer survivors with a confirmed cancer diagnosis from 1996 to 2016 were sampled from the Utah Cancer Registry. The Oral Health Impact Profile-14 (OHIP-14) questionnaire was administrated between January and May of 2019. The impact of oral health on QoL was evaluated using simple linear regression (β-coefficient).Among the 260 oropharyngeal cancer survivors, the majority were male (84.6 %) and ≥ 60 years of age at the time of cancer diagnosis (74.0 %). The most frequently reported symptoms of OHIP-14 were discomfort while eating any foods (19.2 %) and worsening sense of taste (16.0 %). The overall OHIP-14 mean score was 13.3. Significantly worse OHIP-14 scores were observed for females (β = 12.85, p = 0.01), chemotherapy recipients (β = 6.60, p = 0.02), and past smokers (β = 5.25, p = 0.04). Better OHIP-14 scores (better oral QoL) were observed in patients with distant cancer stage (β = -7.66, p = 0.01), higher income (β = -2.50, p = 0.05), and older age at cancer diagnosis (β = -0.35, p = 0.03).The oral health-related quality of life scores observed in this pilot study suggest a need for improvement in patient symptom management over time.Copyright © 2024. Published by Elsevier Ltd.