卵巢癌 (OC) 的维持治疗 (MT) 对于预防疾病复发至关重要。姜黄酚具有有效的抗OC能力，对正常卵巢上皮细胞毒性低，但生物利用度较低。在此，制备了胶束负载姜黄酚（MC）并在OC细胞上检测了MC的抗肿瘤能力。结果表明，MC在两种OC细胞中的IC50值分别为37.69±2.43和28.54±1.58μg/mL。从机制上讲，姜黄酚可以与 AKTThr308 位点相互作用，抑制 FOXO3a 的磷酸化，从而促进 FOXO3a 核定位并将其招募到 PERK 启动子，激活 ERS ​​诱导的细胞凋亡途径。此外，MC可抑制荷瘤裸鼠SKOV3细胞的生长，DiR标记的MC可在肿瘤区域快速积累。 MC 为基于天然产物活性成分的纳米平台实现 OC 的高效 MT 提供了巨大的可行性。版权所有 © 2024 作者。由爱思唯尔公司出版。保留所有权利。

Maintenance therapy (MT) for ovarian cancer (OC) is crucial for preventing disease relapse. Curcumol shows effective anti-OC ability and low-toxicity to the normal ovarian epithelial cells, however, its bioavailability is low. Herein, micellar loaded curcumol (MC) was prepared and the anti-tumor ability of MC were performed on OC cells. The results indicated that the IC50 values of MC in two kinds of OC cells were 37.69 ± 2.43 and 28.54 ± 1.58 μg/mL, respectively. Mechanistically, curcumol could interact with the AKTThr308 site, inhibiting the phosphorylation of FOXO3a, which promoted FOXO3a nuclear locating and recruited it to the PERK promoter, activating the ERS induced apoptosis pathway. Moreover, MC inhibited the growth of SKOV3 cells on tumor-bearing nude mice and the DiR-labeled MC could quickly accumulate in the tumor region. MC provides great feasibility to achieve efficient MT for OC based on the nanoplatforms of active ingredients from natural products.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.