中性粒细胞最近在癌症中受到越来越多的关注，因为它们对所有阶段的癌症都有影响。迄今为止，中性粒细胞被认为具有较短的半衰期。然而，越来越多的文献表明，肿瘤相关中性粒细胞（TAN）的寿命更长。这篇综述讨论了围绕中性粒细胞在肿瘤微环境 (TME) 中持续存在的机制的最新研究。它还强调了针对促肿瘤中性粒细胞的治疗靶向的不同方案，支持这样的观点：在肿瘤中，抑制中性粒细胞募集是不够的，因为这些细胞可以持续存在并在当前的干预中保持隐藏状态。因此，应努力消除长寿命中性粒细胞，以提高标准治疗的疗效。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Neutrophils have recently received increased attention in cancer because they contribute to all stages of cancer. Neutrophils are so far considered to have a short half-life. However, a growing body of literature has shown that tumor-associated neutrophils (TANs) acquire a prolonged lifespan. This review discusses recent work surrounding the mechanisms by which neutrophils can persist in the tumor microenvironment (TME). It also highlights different scenarios for therapeutic targeting of protumorigenic neutrophils, supporting the idea that, in tumors, inhibition of neutrophil recruitment is not sufficient because these cells can persist and remain hidden from current interventions. Hence, the elimination of long-lived neutrophils should be pursued to increase the efficacy of standard therapy.Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.