癌症基因组有时会走最长的进化之路。
Cancer Genomes Sometimes Take the Longest Evolutionary Road.
发表日期：2024 Oct 04
作者：
Alison M Taylor
来源：
Cancer Discovery
摘要：
Baker及其同事开发了一种名为“癌症获得路径识别和计时”（GRITIC）的新算法，以揭示肿瘤中染色体进化的路径，特别是在全基因组复制的背景下。他们的方法发现，基因组加倍的肿瘤经常采取从一种拷贝数状态到另一种拷贝数状态的间接路径。此外，肿瘤进化过程中基因组加倍的时间会影响其对下游染色体不稳定性的影响。请参阅 Baker 等人的相关文章，第 17 页。 1810.©2024 美国癌症研究协会。
Baker and colleagues developed a new algorithm called "Gain Route Identification and Timing In Cancer" (GRITIC) to uncover the path of chromosomal evolution in a tumor, particularly in the context of whole-genome duplication. Their approach found that tumors with genome doubling frequently take an indirect path from one copy number state to another. In addition, the timing of genome doubling within a tumor's evolution impacts its consequences on downstream chromosomal instability. See related article by Baker et al., p. 1810.©2024 American Association for Cancer Research.