肿瘤进展的新视角：通过功能选择进行进化。
A new perspective on tumor progression: Evolution via selection for function.
发表日期：2024
作者：
Frédéric Thomas, James DeGregori, Andriy Marusyk, Antoine M Dujon, Beata Ujvari, Jean-Pascal Capp, Robert Gatenby, Aurora M Nedelcu
来源：
Evolution Medicine and Public Health
摘要：
肿瘤发生通常归因于涉及细胞和细胞群之间的自然选择的达尔文过程。然而，进展性肿瘤是那些也达到适当的群体表型组成（GPC）的肿瘤。然而，作用于肿瘤 GPC 的选择性过程与经典达尔文进化论（即基于差异生殖成功的自然选择）相关的选择性过程不同，因为肿瘤不是真正的进化个体，并且不表现出适应性的遗传变异。这种复杂的进化场景类似于最近提出的用于生命和非生命系统进化的“功能选择”概念。因此，我们认为，断言达尔文过程单独解释了肿瘤发生和癌症进展的所有特征是不准确的。相反，通过产生创建新型 GPC 所需的遗传和表型多样性，这些过程促进了依赖于肿瘤水平功能选择的肿瘤进化成功。© 作者 2024。由牛津大学出版社代表出版进化、医学和公共卫生基金会的成员。
Tumorigenesis is commonly attributed to Darwinian processes involving natural selection among cells and groups of cells. However, progressing tumors are those that also achieve an appropriate group phenotypic composition (GPC). Yet, the selective processes acting on tumor GPCs are distinct from that associated with classical Darwinian evolution (i.e. natural selection based on differential reproductive success) as tumors are not genuine evolutionary individuals and do not exhibit heritable variation in fitness. This complex evolutionary scenario is analogous to the recently proposed concept of 'selection for function' invoked for the evolution of both living and non-living systems. Therefore, we argue that it is inaccurate to assert that Darwinian processes alone account for all the aspects characterizing tumorigenesis and cancer progression; rather, by producing the genetic and phenotypic diversity required for creating novel GPCs, these processes fuel the evolutionary success of tumors that is dependent on selection for function at the tumor level.© The Author(s) 2024. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health.