心血管疾病（CVD）是儿童癌症幸存者（CCS）死亡的主要原因，可能与放疗或化疗的心脏毒性作用以及随之而来的心肺健康下降有关。因此，我们试图比较 CCS 和年龄匹配的非癌症对照 (CON) 之间的心肺健康（峰值摄氧量，V̇O2peak）。次要结局包括血流动力学和静息心功能。从成立到 2023 年 6 月，我们在 Embase、Scopus、MEDLINE、CINAHL 和 SPORTDiscus 数据库中搜索了符合条件的研究。包括在 CCS 和 CON 中测量的 V̇O2peak 的横断面研究。结果的差异和每个结果的汇总估计值通过固定效应荟萃分析进行估计，组间差异报告为加权平均差 (WMD)。在 2026 年确定的研究中，有 18 项报告了 V̇O2peak（CCS：n=786，44%）女性，平均年龄：16 岁，治疗后时间：5.8 年；CON：n=1379，50% 女性，平均年龄：16 岁）。 CCS 中的 V̇O2peak 较低（WMD：-7.08mL/kg/min，95% CI：-7.75 至 -6.42，I2：79%，n=2,165），峰值运动心率没有差异（WMD：-1.4bpm， 95% CI：-3.0 至 0.2，I2：63%，n=741)。静息左心室射血分数（WMD：-1.61%，95% CI：-2.60至-0.62，I2.：49%，n=222）和收缩压较低（WMD：-3.8mmHg，95% CI： -5.7 至 -1.9，I2：25%，n=184），而 CCS 的静息心率较高（WMD：4.9bpm；95% CI：1.8 至 7.9，I2：55%，n=262）。CCS 具有心肺健康显着下降（比 CON 低 7.1 毫升/公斤/分钟），这可能对其未来的 CVD 和死亡风险产生重要的预后影响。© 作者 2024 年。由牛津大学出版社代表欧洲学会出版心脏病学。

Cardiovascular disease (CVD) is a leading cause of mortality in childhood cancer survivors (CCS) that may be related to the cardiotoxic effects of radiation or chemotherapy and concomitant reductions in cardiorespiratory fitness. Therefore, we sought to compare cardiorespiratory fitness (peak oxygen uptake, V̇O2peak) between CCS and age-matched non-cancer controls (CON). Secondary outcomes included hemodynamics and resting cardiac function.Embase, Scopus, MEDLINE, CINAHL and SPORTDiscus databases were searched from inception to June 2023 for eligible studies. Cross-sectional studies with V̇O2peak measured in CCS and CON were included. Differences in outcomes and pooled estimates for each outcome were estimated from a fixed effects meta-analysis and between group differences were reported as a weighted mean difference (WMD).Of 2026 studies identified, 18 reported V̇O2peak (CCS: n=786, 44% female, mean age: 16-years, time post-therapy: 5.8 years; CON: n=1379, 50% female, mean age: 16-years). V̇O2peak was lower in CCS (WMD: -7.08mL/kg/min, 95% CI: -7.75 to -6.42, I2: 79%, n=2,165) with no difference for peak exercise heart rate (WMD: -1.4bpm, 95% CI: -3.0 to 0.2, I2: 63%, n=741). Resting left-ventricular ejection fraction (WMD: -1.61%, 95% CI: -2.60 to -0.62, I2.: 49%, n=222) and systolic blood pressure were lower (WMD: -3.8mmHg, 95% CI: -5.7 to -1.9, I2: 25%, n=184) while resting heart rate was higher in CCS (WMD: 4.9bpm; 95% CI: 1.8 to 7.9, I2: 55%, n=262).CCS have a marked reduction in cardiorespiratory fitness (7.1ml/kg/min lower than CON) that may have important prognostic implications for their future risk of CVD and mortality.© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.