黑暗中的火花：发现脑肿瘤的动作电位。
Spark in the darkness: Discovering action potentials in brain tumors.
发表日期：2024 Oct 14
作者：
Nikolas Andreas Stevens, Nina Drewa, Varun Venkataramani
来源：
CANCER CELL
摘要：
神经胶质瘤表现出显着的分子多样性和不良预后。在本期《癌细胞》中，Curry 等人。将 Patch-seq 应用于人类神经胶质瘤样本，发现具有神经胶质和神经元特征的杂交细胞，能够在异柠檬酸脱氢酶突变型神经胶质瘤中激发动作电位。这些发现强调了神经特征在肿瘤生物学和进展中的重要性。版权所有 © 2024 Elsevier Inc. 保留所有权利。
Gliomas exhibit significant molecular diversity and poor prognosis. In this issue of Cancer Cell, Curry et al. apply Patch-seq on human glioma samples uncovering hybrid cells with glial and neuronal features, capable of firing action potentials in isocitrate dehydrogenase mutant gliomas. These findings highlight the importance of neural features in tumor biology and progression.Copyright © 2024 Elsevier Inc. All rights reserved.