雄激素剥夺疗法 (ADT) 会导致瘦体重 (LM) 损失以及力量和身体功能下降。仅抵抗运动就可以抵消这些变化；然而，尚不清楚添加肌酸补充剂是否可以进一步预防这些 ADT 引起的毒性。我们比较了接受 ADT 的前列腺癌患者补充肌酸联合抗阻运动与单独抗阻运动对 LM、肌肉力量和身体功能的影响。一项为期 12 周的随机试验。接受 ADT 的前列腺癌男性 (n=30)随机分配到抗阻运动安慰剂 (PLA) 或抗阻运动肌酸 (SUPP) 组，两组均每周进行 3 天的监督运动。结果包括通过双能 X 射线吸收测定法评估的全身和四肢 LM 和脂肪量 (FM)，以及肌肉力量（胸部推举、坐姿低位、腿部推举）和身体功能（定时起身、基线和干预后进行评估（椅子起立、400 米步行）。患者年龄 59-84 岁，BMI 为 28.6kg·m-2。 PLA 平均完成 30 节课程 (83%)，SUPP 平均完成 33 节课程 (92%)。尽管组内全身 LM（PLA 0.6kg，SUPP 1.3kg）、四肢 LM（PLA 0.5kg，SUPP 0.6kg）、肌肉力量（PLA 8.8-49.3kg，SUPP 9.4- 40.4kg）和身体功能，组间没有差异（p=0.078-0.951）。没有因补充肌酸或抗阻运动而导致不良事件的报告。单独的短期抗阻运动计划可显着改善 LM、肌肉力量和身体功能，且肌酸补充不会产生额外影响。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Androgen deprivation therapy (ADT) leads to loss of lean mass (LM) and reduced strength and physical function. Resistance exercise alone can counteract these changes; however, it is unknown if the addition of creatine supplementation can further protect against these ADT-induced toxicities. We compared the effects of creatine supplementation with resistance exercise versus resistance exercise alone in patients with prostate cancer undergoing ADT on LM, muscle strength, and physical function.A 12-week randomized trial.Men with prostate cancer receiving ADT (n = 30) were randomized to either resistance exercise + placebo (PLA) or resistance exercise + creatine (SUPP), with both groups undertaking supervised exercise 3 days per week. Outcomes included whole body and appendicular LM and fat mass (FM) assessed by dual-energy X-ray absorptiometry, as well as muscle strength (chest press, seated low, leg press), and physical function (timed up-and-go, chair rise, 400-m walk) assessed at baseline and following the intervention.Patients were aged 59-84 years with a BMI of 28.6 kg·m-2. PLA completed a mean of 30 sessions (83 %) and SUPP a mean of 33 sessions (92 %). Despite similar within-group improvements (p < 0.05) in whole-body LM (PLA +0.6 kg, SUPP +1.3 kg), appendicular LM (PLA +0.5 kg, SUPP +0.6 kg), muscle strength (PLA +8.8-49.3 kg, SUPP +9.4-40.4 kg) and physical function, there were no between group differences (p = 0.078-0.951). No adverse events were reported due to creatine supplementation or resistance exercise.A short-term program of resistance exercise alone results in meaningful improvements in LM, muscle strength and physical function, with no additional effects of creatine supplementation.Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.