研究了一次或一段时间内测量的腰围（WC）和体重指数（BMI）与癌症发病率的关系。 WC 与一些癌症相关，与 BMI 无关。缺乏累积中心性肥胖和癌症的分析。我们调查了腰围年数（纳入男性 WC ≥ 102 cm 或女性 ≥88 cm 的暴露时间）与癌症之间的关联，并将其与单一 WC 或 BMI 进行比较。在前瞻性动脉粥样硬化风险中进行了 9 年以上的系列 WC 测量社区研究 (ARIC) 预测每年的厕所。 Cox 比例风险回归估计了第 4 次访问中测量的腰围年数、WC 或 BMI 癌症发病率的风险比 (HR)。Harrell 的 C 统计量量化了指标预测性能。从第 4 次访问中跟踪了 10,172 名参与者的癌症发病率中位数男性13.7岁，女性15.8岁。对于肥胖相关癌症，每标准差腰围年的 HR 分别为 1.14 (95% CI:1.04,1.25) 和 1.19 (95% CI:1.12,1.27)。度量预测性能的差异微乎其微。这是第一项确定腰围年龄与癌症之间正相关的研究。除了 WC 和 BMI 之外，腰围年数并不能提供有关癌症风险的其他信息。 BMI 在临床中常规测量，因此可能优于 WC。© 2024。作者。

Associations of waist circumferences (WC) and body mass index (BMI) measured once or over time, with cancer incidence were studied. WC is associated with some cancers independent of BMI. Analyses of cumulative central adiposity and cancer are lacking. We investigated associations between waist circumference-years, incorporating exposure time to WC ≥ 102 cm in men or ≥88 cm in women, and cancer, and compared this with single WC or BMI.Serial WC measurements taken over 9 years in the prospective Atherosclerosis Risk in Communities Study (ARIC) predicted yearly WC. Cox proportional hazards regression estimated hazard ratios (HRs) of cancer incidence for waist circumference-years, WC or BMI, measured in Visit 4. Harrell's C-statistic quantified metric predictive performances.10,172 participants were followed up from Visit 4 for cancer over a median 13.7 for men and 15.8 years for women. For obesity-related cancers, HRs per standard deviation waist circumference-years were 1.14 (95%CI:1.04,1.25) and 1.19 (95%CI:1.12,1.27), respectively. Differences in metric predictive performances were marginal.This is the first study to identify positive associations between waist circumference-years and cancer. Waist circumference-years did not provide additional information on cancer risk beyond that of WC and BMI. BMI is routinely measured in clinic so it may be preferred over WC.© 2024. The Author(s).