腰围年和癌症风险：对预测性能与腰围和体重指数的相关性和比较的前瞻性研究
Waist circumference-years and cancer risk: a prospective study of the association and comparison of predictive performance with waist circumference and body mass index
影响因子:6.80000
分区:医学2区 Top / 肿瘤学2区
发表日期:2024 Nov
作者:
Nadin Hawwash, Matthew Sperrin, Glen P Martin, Corinne E Joshu, Roberta Florido, Elizabeth A Platz, Andrew G Renehan
摘要
研究或随着时间的推移测得的腰围圆周（WC）和体重指数（BMI）的关联进行了研究。 WC与某些与BMI无关的癌症相关。缺乏累积中枢性肥胖和癌症的分析。我们调查了腰围年份之间的关联，将男性的暴露时间与女性和癌症的≥88cm合并到≥102cm，并将其与单个WC或BMI.Serial WC进行了比较。在社区研究（ARIC）研究中，前瞻性动脉粥样硬化风险在9年中进行了9年的WC测量。 COX比例危害回归回归估计的腰围年度癌症发生率（HRS）WC或BMI，在访问中测量4。Harrell的C统计量化量化度量预测性能。10,172名参与者在男性中间有13.7岁的癌症访问和女性15.8岁的癌症的访问中随访4。对于与肥胖相关的癌症，每个标准偏差腰围年的HRS分别为1.14（95％CI：1.04,1.25）和1.19（95％CI：1.12,1.27）。度量预测性能的差异是边缘性的。这是第一项鉴定腰围年与癌症之间积极关联的研究。腰围年没有提供有关WC和BMI以外的癌症风险的其他信息。 BMI通常在诊所中测量，因此比WC优选。
Abstract
Associations of waist circumferences (WC) and body mass index (BMI) measured once or over time, with cancer incidence were studied. WC is associated with some cancers independent of BMI. Analyses of cumulative central adiposity and cancer are lacking. We investigated associations between waist circumference-years, incorporating exposure time to WC ≥ 102 cm in men or ≥88 cm in women, and cancer, and compared this with single WC or BMI.Serial WC measurements taken over 9 years in the prospective Atherosclerosis Risk in Communities Study (ARIC) predicted yearly WC. Cox proportional hazards regression estimated hazard ratios (HRs) of cancer incidence for waist circumference-years, WC or BMI, measured in Visit 4. Harrell's C-statistic quantified metric predictive performances.10,172 participants were followed up from Visit 4 for cancer over a median 13.7 for men and 15.8 years for women. For obesity-related cancers, HRs per standard deviation waist circumference-years were 1.14 (95%CI:1.04,1.25) and 1.19 (95%CI:1.12,1.27), respectively. Differences in metric predictive performances were marginal.This is the first study to identify positive associations between waist circumference-years and cancer. Waist circumference-years did not provide additional information on cancer risk beyond that of WC and BMI. BMI is routinely measured in clinic so it may be preferred over WC.