血管肉瘤的基因组景观与临床前模型
Genomic landscape and preclinical models of angiosarcoma
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影响因子:4.5
分区:医学2区 / 肿瘤学3区
发表日期:2025 Apr
作者:
Annaleigh Benton, Bozhi Liu, Lauren E Gartenhaus, Jason A Hanna
DOI:
10.1002/1878-0261.13744
摘要
血管肉瘤是一种在血管或淋巴管中发生的恶性肿瘤，由于其稀有性和侵袭性，临床治疗面临巨大挑战。几十年来，临床结局未见改善，亟需创新的治疗策略。从遗传角度来看，血管肉瘤表现出高度异质性和复杂性，伴随多种反复出现的突变。然而，最新研究已在解剖和分子亚组中发现一些共同特征。为了识别潜在的治疗脆弱点，理解并整合血管肉瘤的突变景观及其现有的模型研究体系至关重要。本文总结了血管肉瘤不同分子和解剖亚型的基因组变化的研究成果，讨论了几种潜在的可操作靶点，并强调了该领域现有的临床前模型。
Abstract
Angiosarcoma is a cancer that develops in blood or lymphatic vessels that presents a significant clinical challenge due to its rarity and aggressive features. Clinical outcomes have not improved in decades, highlighting a need for innovative therapeutic strategies to treat the disease. Genetically, angiosarcomas exhibit high heterogeneity and complexity with many recurrent mutations. However, recent studies have identified some common features within anatomic and molecular subgroups. To identify potential therapeutic vulnerabilities, it is essential to understand and integrate the mutational landscape of angiosarcoma with the models that exist to study the disease. In this review, we will summarize the insights gained from reported genomic alterations in molecular and anatomic subtypes of angiosarcoma, discuss several potential actionable targets, and highlight the preclinical disease models available in the field.