血管肉瘤的基因组景观和临床前模型
Genomic landscape and preclinical models of angiosarcoma
影响因子:4.50000
分区:医学2区 / 肿瘤学3区
发表日期:2025 Apr
作者:
Annaleigh Benton, Bozhi Liu, Lauren E Gartenhaus, Jason A Hanna
摘要
血管肉瘤是一种在血液或淋巴血管中发展的癌症，由于其稀有性和侵略性，引起了重大临床挑战。几十年来，临床结局并没有改善，这突出了需要创新治疗策略来治疗疾病。从遗传上讲，血管肉瘤表现出高的异质性和复杂性，并具有许多复发性突变。但是，最近的研究确定了解剖和分子亚组中的一些共同特征。为了识别潜在的治疗脆弱性，必须了解和整合血管肉瘤的突变景观与研究该疾病的模型。在这篇综述中，我们将总结从报道的分子和解剖亚型的基因组改变所获得的见解，讨论几个潜在的可行靶标，并突出该领域可用的临床前疾病模型。
Abstract
Angiosarcoma is a cancer that develops in blood or lymphatic vessels that presents a significant clinical challenge due to its rarity and aggressive features. Clinical outcomes have not improved in decades, highlighting a need for innovative therapeutic strategies to treat the disease. Genetically, angiosarcomas exhibit high heterogeneity and complexity with many recurrent mutations. However, recent studies have identified some common features within anatomic and molecular subgroups. To identify potential therapeutic vulnerabilities, it is essential to understand and integrate the mutational landscape of angiosarcoma with the models that exist to study the disease. In this review, we will summarize the insights gained from reported genomic alterations in molecular and anatomic subtypes of angiosarcoma, discuss several potential actionable targets, and highlight the preclinical disease models available in the field.