癌症是一种以获得多种独特特征为特征的疾病。人们很早就知道癌细胞会显着偏离正常细胞的代谢。最明显的代谢变化是癌细胞强烈依赖有氧糖酵解的葡萄糖转化。此外，他们还定期开发利用脂质和脂肪酸满足能量需求的机制。过氧化物酶体对于脂质代谢的这些适应性变化至关重要。过氧化物酶体是代谢细胞器，参与 50 多种对细胞功能至关重要的酶反应。因此，它们对于有效和全面地利用向细胞提供的脂质能量至关重要。癌细胞表现出过氧化物酶体生物发生的显着增加以及过氧化物酶体提供的酶功能所需的蛋白质表达的增加。此外，过氧化物酶体中 FA 的酶促转化是活性氧和氮物种 (ROS/RNS) 的重要来源，对癌症恶性肿瘤有强烈影响。过氧化物酶体 FA 氧化和 ROS/RNS 生成的重要调节因子是过氧化物酶体增殖物激活受体 (PPAR) 家族的转录因子。本综述描述了受过氧化物酶体影响的肿瘤发生和癌症进展的代谢变化。我们将强调过氧化物酶体和 PPAR 在肿瘤发展的不同阶段所发挥的矛盾作用，并总结我们目前对如何利用过氧化物酶体生物学的理解来治疗癌症的理解。版权所有 © 2024。由 Elsevier GmbH 出版。

Cancer is a disease characterized by the acquisition of a multitude of unique traits. It has long been understood that cancer cells divert significantly from normal cell metabolism. The most obvious of metabolic changes is that cancer cells strongly rely on glucose conversion by aerobic glycolysis. In addition, they also regularly develop mechanisms to use lipids and fatty acids for their energy needs. Peroxisomes lie central to these adaptive changes of lipid metabolism. Peroxisomes are metabolic organelles that take part in over 50 enzymatic reactions crucial for cellular functioning. Thus, they are essential for an effective and comprehensive use of lipids' energy supplied to cells. Cancer cells display a substantial increase in the biogenesis of peroxisomes and an increased expression of proteins necessary for the enzymatic functions provided by peroxisomes. Moreover, the enzymatic conversion of FAs in peroxisomes is a significant source of reactive oxygen and nitrogen species (ROS/RNS) that strongly impact cancer malignancy. Important regulators in peroxisomal FA oxidation and ROS/RNS generation are the transcription factors of the peroxisome proliferator-activated receptor (PPAR) family. This review describes the metabolic changes in tumorigenesis and cancer progression influenced by peroxisomes. We will highlight the ambivalent role that peroxisomes and PPARs play in the different stages of tumor development and summarize our current understanding of how to capitalize on the comprehension of peroxisomal biology for cancer treatment.Copyright © 2024. Published by Elsevier GmbH.