探索细胞外囊泡（EV）在病毒传播和复制中的作用的最新研究进展阐明了嗜肝病毒，例如甲型肝炎（HAV）、乙型肝炎（HBV）、丙型肝炎（HCV）、丁型肝炎（HDV）和戊型肝炎（HEV）。虽然之前的研究已经揭示了这些病毒利用细胞 EV 途径进行复制和传播的能力，但大多数研究都集中在外泌体途径的影响上。随着对 EV 的了解不断加深，四种主要亚型，包括外泌体、微泡、大肿瘤体和凋亡小体，已根据大小和生物途径进行了分类。然而，在总结最近的发现并概述与嗜肝病毒相关的 EV 研究的未来前景的综合评论中仍然存在明显的差距。本综述旨在巩固对嗜肝病毒利用的EV途径的见解，为该领域的未来研究方向提供指导。通过了解各种嗜肝病毒相关的 EV 及其在生产性病毒感染期间细胞通讯中的作用，这篇综述可能为靶向治疗和制定对抗强效嗜肝病毒感染和相关肝癌发病率的策略提供有价值的见解。© 2024 . 作者。

Recent advances in studies exploring the roles of extracellular vesicles (EVs) in viral transmission and replication have illuminated hepatotropic viruses, such as hepatitis A (HAV), hepatitis B (HBV), hepatitis C (HCV), hepatitis D (HDV), and hepatitis E (HEV). While previous investigations have uncovered these viruses' ability to exploit cellular EV pathways for replication and transmission, most have focused on the impacts of exosomal pathways. With an improved understanding of EVs, four main subtypes, including exosomes, microvesicles, large oncosomes, and apoptotic bodies, have been categorized based on size and biogenic pathways. However, there remains a noticeable gap in comprehensive reviews summarizing recent findings and outlining future perspectives for EV studies related to hepatotropic viruses. This review aims to consolidate insights into EV pathways utilized by hepatotropic viruses, offering guidance for the future research direction in this field. By comprehending the diverse range of hepatotropic virus-associated EVs and their role in cellular communication during productive viral infections, this review may offer valuable insights for targeting therapeutics and devising strategies to combat virulent hepatotropic virus infections and the associated incidence of liver cancer.© 2024. The Author(s).