头颈癌 (HNC) 及其治疗会引起严重疼痛，从而深刻影响患者的生活质量和治疗结果。了解 HNC 疼痛的全部范围对于有效治疗和改善患者护理至关重要。本综述旨在全面分析 HNC 患者所经历的疼痛的多方面性质，包括其各种病因和治疗策略。HNC 疼痛可能因肿瘤范围、治疗相关的毒性或合并症。病理生理学涉及伤害性、神经性和炎症机制之间复杂的相互作用。最佳的疼痛控制需要采用药物和非药物治疗的多模式患者定制方法。增强我们对 HNC 疼痛的理解并优化其管理对于改善受影响个体的整体健康和治疗结果至关重要。未来的研究应侧重于了解详细的疼痛机制，目标是制定个性化的疼痛管理策略和探索新的治疗靶点。通过实施综合的 HNC 疼痛管理方法，医疗保健提供者可以更好地支持患者完成癌症治疗之旅。© 2024 作者。约翰·威利出版的《口腔疾病》

Head and neck cancer (HNC) and its treatments can cause significant pain, which can profoundly impact patients' quality of life and treatment outcomes. Understanding the full scope of HNC pain is essential for effective management and improved patient care.This review aims to comprehensively analyze the multifaceted nature of pain experienced by individuals with HNC, including its various etiologies and management strategies.HNC pain can arise from tumor extent, treatment-related toxicity, or comorbid conditions. The pathophysiology involves complex interactions between nociceptive, neuropathic, and inflammatory mechanisms. Optimal pain control requires a multimodal patient-tailored approach utilizing both pharmacological and non-pharmacological therapies.Enhancing our understanding of HNC pain and optimizing its management is imperative for improving the overall well-being and treatment outcomes of affected individuals. Future research should focus on understanding detailed pain mechanisms, with the goal of developing personalized pain management strategies and exploring novel therapeutic targets. By implementing comprehensive approaches to HNC pain management, healthcare providers can better support patients through their cancer treatment journey.© 2024 The Author(s). Oral Diseases published by John Wiley & Sons Ltd.