痛苦的现实：头颈部癌症疼痛的复杂性及应对策略
Painful Realities: Navigating the Complexities of Head and Neck Cancer Pain
DOI 原文链接
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影响因子:2.9
分区:医学3区 / 牙科与口腔外科4区
发表日期:2024 Oct 07
作者:
Hayden F Byrd, Zachary A Kohutek
DOI:
10.1111/odi.15150
摘要
头颈部癌（HNC）及其治疗常引起显著疼痛，严重影响患者的生活质量和治疗效果。全面理解HNC疼痛的范围对于有效管理和改善患者护理至关重要。本综述旨在全面分析HNC患者所经历的多面性疼痛，包括其多种病因和管理策略。HNC疼痛可能由肿瘤范围、治疗相关毒性或伴随疾病引起。其发病机制复杂，涉及伤害感受、神经病理性和炎症反应的交互作用。实现最佳疼痛控制需要采用多模态、个体化的治疗方案，结合药物和非药物疗法。提升对HNC疼痛的理解和优化其管理，是改善患者整体福祉和治疗效果的关键。未来研究应深入探讨疼痛的具体机制，旨在开发个性化的疼痛管理策略和新型治疗靶点。通过实施全面的HNC疼痛管理方案，医护人员能更好地支持患者的癌症治疗过程。
Abstract
Head and neck cancer (HNC) and its treatments can cause significant pain, which can profoundly impact patients' quality of life and treatment outcomes. Understanding the full scope of HNC pain is essential for effective management and improved patient care.This review aims to comprehensively analyze the multifaceted nature of pain experienced by individuals with HNC, including its various etiologies and management strategies.HNC pain can arise from tumor extent, treatment-related toxicity, or comorbid conditions. The pathophysiology involves complex interactions between nociceptive, neuropathic, and inflammatory mechanisms. Optimal pain control requires a multimodal patient-tailored approach utilizing both pharmacological and non-pharmacological therapies.Enhancing our understanding of HNC pain and optimizing its management is imperative for improving the overall well-being and treatment outcomes of affected individuals. Future research should focus on understanding detailed pain mechanisms, with the goal of developing personalized pain management strategies and exploring novel therapeutic targets. By implementing comprehensive approaches to HNC pain management, healthcare providers can better support patients through their cancer treatment journey.