鉴于全球男性前列腺癌的患病率，探索更有效的治疗策略至关重要。最近，免疫疗法因其独特的作用机制和潜在的长期有效性而成为一种有前途的癌症治疗方法。然而，其对前列腺癌的有限疗效激起了人们对制定改善免疫治疗结果的策略的新兴趣。纳米医学以其独特的尺寸效应和表面特性为癌症治疗提供了新的视角。通过采用靶向递送、控制释放和增强的免疫原性，纳米颗粒可以与纳米医学平台协同作用，以增强免疫疗法治疗前列腺癌的有效性。同时，纳米技术可以解决免疫治疗的局限性以及免疫逃逸和肿瘤微环境调节的挑战。此外，纳米医学与其他疗法相结合的协同效应提供了有希望的临床结果。纳米医学的创新应用包括智能纳米载体、刺激响应系统和克服前列腺癌免疫治疗中转化障碍的精准医学方法。本综述强调了纳米医学在增强前列腺癌免疫治疗方面的变革潜力，并强调需要跨学科合作来推动研究和临床应用向前发展。© 2024 Jiang et al.

Given the global prevalence of prostate cancer in men, it is crucial to explore more effective treatment strategies. Recently, immunotherapy has emerged as a promising cancer treatment due to its unique mechanism of action and potential long-term effectiveness. However, its limited efficacy in prostate cancer has prompted renewed interest in developing strategies to improve immunotherapy outcomes. Nanomedicine offers a novel perspective on cancer treatment with its unique size effects and surface properties. By employing targeted delivery, controlled release, and enhanced immunogenicity, nanoparticles can be synergized with nanomedicine platforms to amplify the effectiveness of immunotherapy in treating prostate cancer. Simultaneously, nanotechnology can address the limitations of immunotherapy and the challenges of immune escape and tumor microenvironment regulation. Additionally, the synergistic effects of combining nanomedicine with other therapies offer promising clinical outcomes. Innovative applications of nanomedicine include smart nanocarriers, stimulus-responsive systems, and precision medicine approaches to overcome translational obstacles in prostate cancer immunotherapy. This review highlights the transformative potential of nanomedicine in enhancing prostate cancer immunotherapy and emphasizes the need for interdisciplinary collaboration to drive research and clinical applications forward.© 2024 Jiang et al.