隧道纳米管（TNT）是重要的细胞间通讯通道，可显着影响癌症病理生理学，影响肿瘤进展和耐药性。这篇综述系统地研究了 TNT 的形成机制、其结构特征及其在细胞间物质和信号传递中的功能作用。 TNT 强调其在肿瘤微环境中的调节功能，对于调节细胞存活、增殖、耐药性和免疫逃避至关重要。该综述严格评估了 TNT 的治疗潜力，重点关注其在靶向药物输送和基因治疗中的应用。它还提出了未来的研究方向，以彻底了解 TNT 的生物发生，识别细胞特异性分子靶点，并开发实时监测 TNT 的先进技术。通过整合分子生物学、纳米技术和免疫学的见解，这篇综述强调了 TNT 在推进癌症治疗策略方面的变革潜力。

Tunneling nanotubes (TNTs) are essential intercellular communication channels that significantly impact cancer pathophysiology, affecting tumor progression and resistance. This review methodically examines the mechanisms of TNTs formation, their structural characteristics, and their functional roles in material and signal transmission between cells. Highlighting their regulatory functions within the tumor microenvironment, TNTs are crucial for modulating cell survival, proliferation, drug resistance, and immune evasion. The review critically evaluates the therapeutic potential of TNTs, focusing on their applications in targeted drug delivery and gene therapy. It also proposes future research directions to thoroughly understand TNTs biogenesis, identify cell-specific molecular targets, and develop advanced technologies for the real-time monitoring of TNTs. By integrating insights from molecular biology, nanotechnology, and immunology, this review highlights the transformative potential of TNTs in advancing cancer treatment strategies.