韩国40岁以下围绝经期女性身高与乳腺癌风险的关系研究
Height and breast cancer risk in premenopausal Korean women aged under 40 years of age
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影响因子:6.8
分区:医学2区 Top / 肿瘤学2区
发表日期:2024 Dec
作者:
Thi Xuan Mai Tran, Yoosoo Chang, Hye Rin Choi, Ria Kwon, Ga-Young Lim, Yoosun Cho, Seungho Ryu, Boyoung Park
DOI:
10.1038/s41416-024-02846-w
摘要
身高较高的女性患乳腺癌的风险增加；然而，关于年轻女性的相关证据有限。本研究调查了韩国40岁以下围绝经期女性中身高与乳腺癌风险的关系。在Kangbuk Samsung Health Study（KSHS）和国家健康保险服务-国家健康信息数据库（NHIS-NHID）中注册的40岁以下围绝经期女性均纳入分析。由受过培训的工作人员进行身高等人体测量。乳腺癌发病情况追踪至2019年12月。采用Cox回归模型和限制性立方样条回归分析。两队列的平均（标准差）年龄分别为33.3（3.6）和32.9（4.2）岁。调整基线年龄及其他混杂因素后，KSHS中每增加10厘米身高，乳腺癌的风险增加1.44倍（调整后风险比[aHR]，1.44；95%置信区间[CI]，1.17-1.78）。限制性立方样条回归显示身高与乳腺癌风险几乎呈线性关系。与身高<155厘米的女性相比，身高在160-165厘米、165-170厘米及≥170厘米的女性的aHR（95% CI）分别为1.67（1.07-2.60）、1.75（1.09-2.81）和2.31（1.18-3.86）(P=0.009)。NHIS-NHID队列的结果类似（每10厘米身高增加，aHR为1.20，95% CI为1.10-1.31）。在年轻韩国女性中，身高越高，乳腺癌风险越大。
Abstract
Taller women are at an increased risk of breast cancer; however, evidence regarding this in younger women is limited. This study investigated the association between body height and breast cancer risk in premenopausal Korean women aged <40 years.Premenopausal women aged <40 years enroled in the Kangbuk Samsung Health Study (KSHS) and National Health Insurance Service-National Health Information Database (NHIS-NHID) were included in the analysis. Trained staff members performed anthropometry, including height measurements. Breast cancer incidence was followed up until December 2019. Cox regression model and restricted cubic- spline regression were applied.The mean (standard deviation [SD]) age was 33.3 (3.6) years and 32.9 (4.2) in KSHS and NHIS-NHID cohorts, respectively. After adjusting for age at baseline and other confounders, every 10 cm of height was associated with a 1.44-fold increased risk of developing breast cancer (adjusted hazard ratio [aHR], 1.44; 95% confidence interval [CI], 1.17-1.78) in the KSHS. The restricted cubic spline regression showed an almost linear association between height and breast cancer risk. Compared to women with height <155 cm, aHRs (95% CI) among those with height 160-165 cm, 165-170 cm, and ≥170 cm were 1.67 (1.07-2.60), 1.75 (1.09-2.81), and 2.31 (1.18-3.86), respectively (P = 0.009). Results were similar in the NHIS-NHID cohort (aHR, 1.20 [95% CI, 1.10-1.31] per 10-cm increase in height).In young Korean women, greater body height was associated with increased breast cancer risk.