研究动态
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40 岁以下绝经前韩国女性的身高和乳腺癌风险。

Height and breast cancer risk in premenopausal Korean women aged under 40 years of age.

发表日期:2024 Oct 07
作者: Thi Xuan Mai Tran, Yoosoo Chang, Hye Rin Choi, Ria Kwon, Ga-Young Lim, Yoosun Cho, Seungho Ryu, Boyoung Park
来源: BRITISH JOURNAL OF CANCER

摘要:

个子较高的女性患乳腺癌的风险更高;然而,有关年轻女性这一点的证据有限。本研究调查了年龄 <40 岁的绝经前韩国女性的身高与乳腺癌风险之间的关系。年龄 <40 岁的绝经前女性参加了江北三星健康研究 (KSHS) 和国民健康保险公团国民健康信息数据库 (NHIS- NHID) 被纳入分析中。训练有素的工作人员进行人体测量,包括身高测量。乳腺癌发病率随访至2019年12月。应用Cox回归模型和限制三次样条回归。KSHS和NHIS-NHID队列的平均(标准差[SD])年龄分别为33.3(3.6)岁和32.9(4.2)岁, 分别。调整基线年龄和其他混杂因素后,身高每增加 10 厘米,患乳腺癌的风险就会增加 1.44 倍(调整后的风险比 [aHR],1.44;95% 置信区间 [CI],1.17-1.78)在 KSHS 中。受限三次样条回归显示身高和乳腺癌风险之间几乎呈线性相关。与身高<155厘米的女性相比,身高160-165厘米、165-170厘米和≥170厘米的女性的aHR(95% CI)分别为1.67(1.07-2.60)、1.75(1.09-2.81)和2.31分别为(1.18-3.86)(P = 0.009)。 NHIS-NHID 队列的结果相似(身高每增加 10 厘米,aHR,1.20 [95% CI,1.10-1.31])。在年轻的韩国女性中,较高的身高与乳腺癌风险增加相关。© 2024。作者获得施普林格自然有限公司的独家许可。
Taller women are at an increased risk of breast cancer; however, evidence regarding this in younger women is limited. This study investigated the association between body height and breast cancer risk in premenopausal Korean women aged <40 years.Premenopausal women aged <40 years enroled in the Kangbuk Samsung Health Study (KSHS) and National Health Insurance Service-National Health Information Database (NHIS-NHID) were included in the analysis. Trained staff members performed anthropometry, including height measurements. Breast cancer incidence was followed up until December 2019. Cox regression model and restricted cubic- spline regression were applied.The mean (standard deviation [SD]) age was 33.3 (3.6) years and 32.9 (4.2) in KSHS and NHIS-NHID cohorts, respectively. After adjusting for age at baseline and other confounders, every 10 cm of height was associated with a 1.44-fold increased risk of developing breast cancer (adjusted hazard ratio [aHR], 1.44; 95% confidence interval [CI], 1.17-1.78) in the KSHS. The restricted cubic spline regression showed an almost linear association between height and breast cancer risk. Compared to women with height <155 cm, aHRs (95% CI) among those with height 160-165 cm, 165-170 cm, and ≥170 cm were 1.67 (1.07-2.60), 1.75 (1.09-2.81), and 2.31 (1.18-3.86), respectively (P = 0.009). Results were similar in the NHIS-NHID cohort (aHR, 1.20 [95% CI, 1.10-1.31] per 10-cm increase in height).In young Korean women, greater body height was associated with increased breast cancer risk.© 2024. The Author(s), under exclusive licence to Springer Nature Limited.