绝经前韩国妇女40岁以下的韩国妇女的身高和乳腺癌风险
Height and breast cancer risk in premenopausal Korean women aged under 40 years of age
影响因子:6.80000
分区:医学2区 Top / 肿瘤学2区
发表日期:2024 Dec
作者:
Thi Xuan Mai Tran, Yoosoo Chang, Hye Rin Choi, Ria Kwon, Ga-Young Lim, Yoosun Cho, Seungho Ryu, Boyoung Park
摘要
高女性患乳腺癌的风险增加。但是，在年轻妇女中有关此的证据是有限的。这项研究调查了年龄在40岁的绝经前韩国妇女中的身体高度和乳腺癌风险之间的关联。在分析中包括了kangbuk三星健康研究（KSHS）和国家健康保险服务国家健康信息数据库（NHIS-NHID）的少年妇女。训练有素的工作人员进行了人体测量法，包括高度测量。随访乳腺癌的发生率一直持续到2019年12月。采用COX回归模型和限制的立方晶状体回归。平均值（标准偏差[SD]）年龄分别为33.3（3.6）年，KSHS和NHIS-NHID同类群体分别为32.9（4.2）。调整基线和其他混杂因素的年龄后，每10厘米的高度与患乳腺癌的风险增加了1.44倍（调整后危险比[AHR]，1.44; 95％置信区间[CI]，1.17-1.78，1.17-1.78）在KSHS中。限制的立方样条回归显示高度和乳腺癌风险之间几乎是线性的关联。与高度<155 cm的女性相比，高度160-165 cm，165-170 cm和≥170cm的AHR（95％CI）为1.67（1.07-2.60），1.75（1.09-2.81），分别为1.09-2.81）和2.31（1.18-3.86）（1.18-3.86）。 NHIS-NHID队列的结果相似（AHR，1.20 [95％CI，1.10-1.31]每10 cm的高度增加）。在年轻的韩国妇女中，更高的身体身高与乳腺癌的风险增加有关。
Abstract
Taller women are at an increased risk of breast cancer; however, evidence regarding this in younger women is limited. This study investigated the association between body height and breast cancer risk in premenopausal Korean women aged <40 years.Premenopausal women aged <40 years enroled in the Kangbuk Samsung Health Study (KSHS) and National Health Insurance Service-National Health Information Database (NHIS-NHID) were included in the analysis. Trained staff members performed anthropometry, including height measurements. Breast cancer incidence was followed up until December 2019. Cox regression model and restricted cubic- spline regression were applied.The mean (standard deviation [SD]) age was 33.3 (3.6) years and 32.9 (4.2) in KSHS and NHIS-NHID cohorts, respectively. After adjusting for age at baseline and other confounders, every 10 cm of height was associated with a 1.44-fold increased risk of developing breast cancer (adjusted hazard ratio [aHR], 1.44; 95% confidence interval [CI], 1.17-1.78) in the KSHS. The restricted cubic spline regression showed an almost linear association between height and breast cancer risk. Compared to women with height <155 cm, aHRs (95% CI) among those with height 160-165 cm, 165-170 cm, and ≥170 cm were 1.67 (1.07-2.60), 1.75 (1.09-2.81), and 2.31 (1.18-3.86), respectively (P = 0.009). Results were similar in the NHIS-NHID cohort (aHR, 1.20 [95% CI, 1.10-1.31] per 10-cm increase in height).In young Korean women, greater body height was associated with increased breast cancer risk.