据报道，1 型糖尿病 (T1D) 患者胃肠道癌症的年龄标准化发病率高于一般人群。在调整了共同的风险因素后，我们的目的是探索 T1D 与胃肠道癌症之间的关联，并研究这种关系如何随年龄和性别而变化。这项回顾性队列研究包括来自韩国国家健康保险服务国家样本队列的 268,179 名参与者。主要结果是根据诊断代码发生胃肠道癌症。进行多变量 Cox 回归分析以评估 T1D 与胃肠道癌症之间的关联。在 268,179 名参与者中，2681 人在基线时患有 T1D，并随访了 12.98 (± 2.92) 年。与非 T1D 患者相比，T1D 患者罹患所有胃肠道癌症的风险均显着增加（调整后风险比 [aHR]：1.403，95% 置信区间 [CI]：1.253-1.573）。 T1D患者患食道癌（aHR：1.864，95% CI：1.038-3.349）、胃癌（aHR：1.313，95% CI：1.066-1.616）、结肠癌（aHR：1.365，95% CI：1.110-）的风险增加1.678）、肝癌（aHR：1.388，95% CI：1.115-1.727）和胰腺癌（aHR：1.716，95% CI：1.182-2.492）。这种关联在男性和女性中都存在，并且随着年龄的增长，其强度也随之增强。T1D 患者患胃肠道癌症的风险显着增加。老年男性 T1D 患者表现出更高的风险，表明在护理中需要有针对性的关注。© 2024 John Wiley

The age-standardised incidence ratio of gastrointestinal cancers in type 1 diabetes (T1D) patients has been reported to be higher than that in the general population. After adjusting for shared risk factors, we aimed to explore the association between T1D and gastrointestinal cancer and examine how this relationship varies by age and sex.This retrospective cohort study included 268,179 participants from the Korean National Health Insurance Service-National Sample Cohort. The primary outcome is the incident of gastrointestinal cancers, based on diagnostic codes. Multivariate Cox regression analyses were performed to assess the association between T1D and gastrointestinal cancers.Of the 268,179 participants, 2681 had T1D at baseline and were followed for 12.98 (± 2.92) years. Compared with non-T1D, T1D patients had a significantly increased risk of all gastrointestinal cancer (adjusted hazard ratio [aHR]: 1.403, 95% confidence interval [CI]: 1.253-1.573). T1D patients increased risks of oesophageal cancer (aHR: 1.864, 95% CI: 1.038-3.349), gastric cancer (aHR: 1.313, 95% CI: 1.066-1.616), colon cancer (aHR: 1.365, 95% CI: 1.110-1.678), liver cancer (aHR: 1.388, 95% CI: 1.115-1.727), and pancreatic cancer (aHR: 1.716, 95% CI: 1.182-2.492). The consistency of this association persisted among both male and female, with its strength increasing with older age.The risk of gastrointestinal cancer was significantly increased in T1D patients. Older male T1D patients exhibit a higher risk, suggesting the need for targeted attention in their care.© 2024 John Wiley & Sons Ltd.